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2017 ; 23
(12
): 2095-2105
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Long term follow-up and outcome of liver transplantation from hepatitis B surface
antigen positive donors
#MMPMID28405138
Ballarin R
; Cucchetti A
; Russo FP
; Magistri P
; Cescon M
; Cillo U
; Burra P
; Pinna AD
; Di Benedetto F
World J Gastroenterol
2017[Mar]; 23
(12
): 2095-2105
PMID28405138
show ga
Liver transplant for hepatitis B virus (HBV) currently yields excellent outcomes:
it allows to rescue patients with an HBV-related advanced liver disease,
resulting in a demographical modification of the waiting list for liver
transplant. In an age of patient-tailored treatments, in liver transplantation as
well the aim is to offer the best suitable graft to the patient who can benefit
from it, also expanding the criteria for organ acceptance and allocation. With
the intent of developing strategies to increase the donor pool, we set-up a
multicenter study involving 3 Liver Transplant Centers in Italy: patients
undergoing liver transplantation between March 03, 2004, and May 21, 2010, were
retrospectively evaluated. 1408 patients underwent liver transplantation during
the study period, 28 (2%) received the graft from hepatitis B surface antigen
positive (HBsAg)-positive deceased donors. The average follow-up after liver
transplantation was 63.7 mo [range: 0.1-119.4; SD ± 35.8]. None Primary
non-function, re-liver transplantation, early or late hepatic artery thrombosis
occurred. The 1-, 3- and 5-year graft and patient survival resulted of 85.7%,
82.1%, 78.4%. Our results suggest that the use of HBsAg-positive donors liver
grafts is feasible, since HBV can be controlled without affecting graft
stability. However, the selection of grafts and the postoperative antiviral
therapy should be managed appropriately.