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10.1113/JP272864 http://scihub22266oqcxt.onion/10.1113/JP272864 C5374109!5374109!27861921     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Physiol 2017 ; 595 (7): 2209-28 Nephropedia Template TP {{tp|p=27861921|t=2017. Potassium channels in the heart: structure, function and regulation |pdf=|usr=}}{{27861921}} gab.com Text Potassium channels in the heart: structure, function and regulation JO: J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27861921 #FOAvip This paper is the outcome of the fourth UC Davis Systems Approach to Understanding Cardiac Excitation?Contraction Coupling and Arrhythmias Symposium, a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2016 symposium was ?K+ Channels and Regulation?. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies and challenges on the topic of cardiac K+ channels. This paper summarizes the topics of formal presentations and informal discussions from the symposium on the structural basis of voltage?gated K+ channel function, as well as the mechanisms involved in regulation of K+ channel gating, expression and membrane localization. Given the critical role for K+ channels in determining the rate of cardiac repolarization, it is hardly surprising that essentially every aspect of K+ channel function is exquisitely regulated in cardiac myocytes. This regulation is complex and highly interrelated to other aspects of myocardial function. K+ channel regulatory mechanisms alter, and are altered by, physiological challenges, pathophysiological conditions, and pharmacological agents. An accompanying paper focuses on the integrative role of K+ channels in cardiac electrophysiology, i.e. how K+ currents shape the cardiac action potential, and how their dysfunction can lead to arrhythmias, and discusses K+ channel?based therapeutics. A fundamental understanding of K+ channel regulatory mechanisms and disease processes is fundamental to reveal new targets for human therapy. Twit Text FOAVip Potassium channels in the heart: structure, function and regulation ????J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27861921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27861921 #FOAvip English Wikipedia <ref>{{Cite pmid|27861921}}</ref> Potassium channels in the heart: structure, function and regulation #MMPMID27861921 Grandi E; Sanguinetti MC; Bartos DC; Bers DM; Chen?Izu Y; Chiamvimonvat N; Colecraft HM; Delisle BP; Heijman J; Navedo MF; Noskov S; Proenza C; Vandenberg JI; Yarov?Yarovoy V J Physiol 2017[Apr]; 595 (7): 2209-28 PMID27861921show ga This paper is the outcome of the fourth UC Davis Systems Approach to Understanding Cardiac Excitation?Contraction Coupling and Arrhythmias Symposium, a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2016 symposium was ?K+ Channels and Regulation?. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies and challenges on the topic of cardiac K+ channels. This paper summarizes the topics of formal presentations and informal discussions from the symposium on the structural basis of voltage?gated K+ channel function, as well as the mechanisms involved in regulation of K+ channel gating, expression and membrane localization. Given the critical role for K+ channels in determining the rate of cardiac repolarization, it is hardly surprising that essentially every aspect of K+ channel function is exquisitely regulated in cardiac myocytes. This regulation is complex and highly interrelated to other aspects of myocardial function. K+ channel regulatory mechanisms alter, and are altered by, physiological challenges, pathophysiological conditions, and pharmacological agents. An accompanying paper focuses on the integrative role of K+ channels in cardiac electrophysiology, i.e. how K+ currents shape the cardiac action potential, and how their dysfunction can lead to arrhythmias, and discusses K+ channel?based therapeutics. A fundamental understanding of K+ channel regulatory mechanisms and disease processes is fundamental to reveal new targets for human therapy. äPotassium channels in the heart: structure, function and regulation (epmc).pdf DeepDyve Pubget Overpricing