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10.1172/jci.insight.91634 http://scihub22266oqcxt.onion/10.1172/jci.insight.91634 C5374061!5374061!28405621     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 2 (7): ä Nephropedia Template TP {{tp|p=28405621|t=ä. LipidFinder: A computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets |pdf=|usr=}}{{28405621}} gab.com Text LipidFinder: A computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28405621 #FOAvip Accurate and high-quality curation of lipidomic datasets generated from plasma, cells, or tissues is becoming essential for cell biology investigations and biomarker discovery for personalized medicine. However, a major challenge lies in removing artifacts otherwise mistakenly interpreted as real lipids from large mass spectrometry files (>60 K features), while retaining genuine ions in the dataset. This requires powerful informatics tools; however, available workflows have not been tailored specifically for lipidomics, particularly discovery research. We designed LipidFinder, an open-source Python workflow. An algorithm is included that optimizes analysis based on users? own data, and outputs are screened against online databases and categorized into LIPID MAPS classes. LipidFinder outperformed three widely used metabolomics packages using data from human platelets. We show a family of three 12-hydroxyeicosatetraenoic acid phosphoinositides (16:0/, 18:1/, 18:0/12-HETE-PI) generated by thrombin-activated platelets, indicating crosstalk between eicosanoid and phosphoinositide pathways in human cells. The software is available on GitHub (https://github.com/cjbrasher/LipidFinder), with full userguides. Twit Text FOAVip LipidFinder: A computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28405621 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405621 #FOAvip English Wikipedia <ref>{{Cite pmid|28405621}}</ref> LipidFinder: A computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets #MMPMID28405621 O?Connor A; Brasher CJ; Slatter DA; Meckelmann SW; Hawksworth JI; Allen SM; O?Donnell VB JCI Insight ä[]; 2 (7): ä PMID28405621show ga Accurate and high-quality curation of lipidomic datasets generated from plasma, cells, or tissues is becoming essential for cell biology investigations and biomarker discovery for personalized medicine. However, a major challenge lies in removing artifacts otherwise mistakenly interpreted as real lipids from large mass spectrometry files (>60 K features), while retaining genuine ions in the dataset. This requires powerful informatics tools; however, available workflows have not been tailored specifically for lipidomics, particularly discovery research. We designed LipidFinder, an open-source Python workflow. An algorithm is included that optimizes analysis based on users? own data, and outputs are screened against online databases and categorized into LIPID MAPS classes. LipidFinder outperformed three widely used metabolomics packages using data from human platelets. We show a family of three 12-hydroxyeicosatetraenoic acid phosphoinositides (16:0/, 18:1/, 18:0/12-HETE-PI) generated by thrombin-activated platelets, indicating crosstalk between eicosanoid and phosphoinositide pathways in human cells. The software is available on GitHub (https://github.com/cjbrasher/LipidFinder), with full userguides. äLipidFinder: A computational workflow for discovery of lipids identifi(epmc).pdf DeepDyve Pubget Overpricing