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10.1172/JCI90678 http://scihub22266oqcxt.onion/10.1172/JCI90678 C5373882!5373882 !28287401     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28287401 &cmd=llinks): Failed to open stream: HTTP request failed! 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Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain |pdf=|usr=}}{{28287401 }} gab.com Text Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28287401 #FOAvip Pain is fundamentally unpleasant and induces a negative affective state. The affective component of pain is mediated by circuits that are distinct from those mediating the sensory-discriminative component. Here, we have investigated the role of prostaglandins in the affective dimension of pain using a rodent pain assay based on conditioned place aversion to formalin injection, an inflammatory noxious stimulus. We found that place aversion induced by inflammatory pain depends on prostaglandin E2 that is synthesized by cyclooxygenase 2 in neural cells. Further, mice lacking the prostaglandin E2 receptor EP3 selectively on serotonergic cells or selectively in the area of the dorsal raphe nucleus failed to form an aversion to formalin-induced pain, as did mice lacking the serotonin transporter. Chemogenetic manipulations revealed that EP3 receptor activation elicited conditioned place aversion to pain via inhibition of serotonergic neurons. In contrast to their role in inflammatory pain aversion, EP3 receptors on serotonergic cells were dispensable for acute nociceptive behaviors and for aversion induced by thermal pain or a ? opioid receptor agonist. Collectively, our findings show that prostaglandin-mediated modulation of serotonergic transmission controls the affective component of inflammatory pain. Twit Text FOAVip Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28287401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28287401 #FOAvip English Wikipedia <ref>{{Cite pmid|28287401 }}</ref> Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain #MMPMID28287401 Singh AK ; Zajdel J ; Mirrasekhian E ; Almoosawi N ; Frisch I ; Klawonn AM ; Jaarola M ; Fritz M ; Engblom D J Clin Invest 2017[Apr]; 127 (4 ): 1370-1374 PMID28287401 show ga Pain is fundamentally unpleasant and induces a negative affective state. The affective component of pain is mediated by circuits that are distinct from those mediating the sensory-discriminative component. Here, we have investigated the role of prostaglandins in the affective dimension of pain using a rodent pain assay based on conditioned place aversion to formalin injection, an inflammatory noxious stimulus. We found that place aversion induced by inflammatory pain depends on prostaglandin E2 that is synthesized by cyclooxygenase 2 in neural cells. Further, mice lacking the prostaglandin E2 receptor EP3 selectively on serotonergic cells or selectively in the area of the dorsal raphe nucleus failed to form an aversion to formalin-induced pain, as did mice lacking the serotonin transporter. Chemogenetic manipulations revealed that EP3 receptor activation elicited conditioned place aversion to pain via inhibition of serotonergic neurons. In contrast to their role in inflammatory pain aversion, EP3 receptors on serotonergic cells were dispensable for acute nociceptive behaviors and for aversion induced by thermal pain or a ? opioid receptor agonist. Collectively, our findings show that prostaglandin-mediated modulation of serotonergic transmission controls the affective component of inflammatory pain. |*Pain Perception [MESH] |Affect [MESH] |Animals [MESH] |Cyclooxygenase 2/metabolism [MESH] |Cyclooxygenase Inhibitors/pharmacology [MESH] |Dinoprostone/*physiology [MESH] |Drug Evaluation, Preclinical [MESH] |Inflammation/pathology/psychology [MESH] |Mice, Knockout [MESH] |Pain/*psychology [MESH] |Pyrazoles/pharmacology [MESH] |Receptors, Prostaglandin E, EP3 Subtype/metabolism [MESH] |Serotonergic Neurons/drug effects/*metabolism [MESH] |Serotonin/*physiology [MESH]Prostaglandin-mediated inhibition of serotonin signaling controls the (epmc).pdf DeepDyve Pubget Overpricing