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10.1172/JCI91250 http://scihub22266oqcxt.onion/10.1172/JCI91250 C5373868!5373868!28240602     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 127 (4): 1392-404 Nephropedia Template TP {{tp|p=28240602|t=ä. B cells expressing the transcription factor T-bet drive lupus-like autoimmunity |pdf=|usr=}}{{28240602}} gab.com Text B cells expressing the transcription factor T-bet drive lupus-like autoimmunity JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28240602 #FOAvip B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies. Here we have reported that B cells expressing the transcription factor T-bet promote the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemic lupus erythematosus (SLE). Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in SLE mice. B cell?specific deletion of T-bet was also associated with lower activation of both B cells and T cells. Taken together, our results suggest that targeting T-bet?expressing B cells may be a potential target for therapy for autoimmune diseases. Twit Text FOAVip B cells expressing the transcription factor T-bet drive lupus-like autoimmunity ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28240602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28240602 #FOAvip English Wikipedia <ref>{{Cite pmid|28240602}}</ref> B cells expressing the transcription factor T-bet drive lupus-like autoimmunity #MMPMID28240602 Rubtsova K; Rubtsov AV; Thurman JM; Mennona JM; Kappler JW; Marrack P J Clin Invest ä[]; 127 (4): 1392-404 PMID28240602show ga B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies. Here we have reported that B cells expressing the transcription factor T-bet promote the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemic lupus erythematosus (SLE). Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in SLE mice. B cell?specific deletion of T-bet was also associated with lower activation of both B cells and T cells. Taken together, our results suggest that targeting T-bet?expressing B cells may be a potential target for therapy for autoimmune diseases. äB cells expressing the transcription factor T-bet drive lupus-like aut(epmc).pdf DeepDyve Pubget Overpricing