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10.1172/JCI89281 http://scihub22266oqcxt.onion/10.1172/JCI89281 C5373867!5373867 !28287407     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28287407 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2017 ; 127 (4 ): 1321-1337 Nephropedia Template TP {{tp|p=28287407 |t=2017. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-? signaling |pdf=|usr=}}{{28287407 }} gab.com Text Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF- signaling JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28287407 #FOAvip Moesin is a member of the ezrin-radixin-moesin (ERM) family of proteins that are important for organizing membrane domains and receptor signaling and regulating the migration of effector T cells. Whether moesin plays any role during the generation of TGF-?-induced Tregs (iTregs) is unknown. Here, we have discovered that moesin is translationally regulated by TGF-? and is also required for optimal TGF-? signaling that promotes efficient development of iTregs. Loss of moesin impaired the development and function of both peripherally derived iTregs and in vitro-induced Tregs. Mechanistically, we identified an interaction between moesin and TGF-? receptor II (T?RII) that allows moesin to control the surface abundance and stability of T?RI and T?RII. We also found that moesin is required for iTreg conversion in the tumor microenvironment, and the deletion of moesin from recipient mice supported the rapid expansion of adoptively transferred CD8+ T cells against melanoma. Our study establishes moesin as an important regulator of the surface abundance and stability of T?RII and identifies moesin's role in facilitating the efficient generation of iTregs. It also provides an advancement to our understanding about the role of the ERM proteins in regulating signal transduction pathways and suggests that modulation of moesin is a potential therapeutic target for Treg-related immune disorders. Twit Text FOAVip Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF- signaling ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28287407 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28287407 #FOAvip English Wikipedia <ref>{{Cite pmid|28287407 }}</ref> Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-? signaling #MMPMID28287407 Ansa-Addo EA ; Zhang Y ; Yang Y ; Hussey GS ; Howley BV ; Salem M ; Riesenberg B ; Sun S ; Rockey DC ; Karvar S ; Howe PH ; Liu B ; Li Z J Clin Invest 2017[Apr]; 127 (4 ): 1321-1337 PMID28287407 show ga Moesin is a member of the ezrin-radixin-moesin (ERM) family of proteins that are important for organizing membrane domains and receptor signaling and regulating the migration of effector T cells. Whether moesin plays any role during the generation of TGF-?-induced Tregs (iTregs) is unknown. Here, we have discovered that moesin is translationally regulated by TGF-? and is also required for optimal TGF-? signaling that promotes efficient development of iTregs. Loss of moesin impaired the development and function of both peripherally derived iTregs and in vitro-induced Tregs. Mechanistically, we identified an interaction between moesin and TGF-? receptor II (T?RII) that allows moesin to control the surface abundance and stability of T?RI and T?RII. We also found that moesin is required for iTreg conversion in the tumor microenvironment, and the deletion of moesin from recipient mice supported the rapid expansion of adoptively transferred CD8+ T cells against melanoma. Our study establishes moesin as an important regulator of the surface abundance and stability of T?RII and identifies moesin's role in facilitating the efficient generation of iTregs. It also provides an advancement to our understanding about the role of the ERM proteins in regulating signal transduction pathways and suggests that modulation of moesin is a potential therapeutic target for Treg-related immune disorders. |Adoptive Transfer [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Cell Membrane/metabolism [MESH] |Cells, Cultured [MESH] |Female [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Male [MESH] |Melanoma, Experimental/*immunology/pathology/therapy [MESH] |Mice, 129 Strain [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Microfilament Proteins/*physiology [MESH] |Neoplasm Transplantation [MESH] |Protein Binding [MESH] |Protein Biosynthesis [MESH] |Protein Serine-Threonine Kinases/genetics/metabolism [MESH] |Protein Stability [MESH] |Protein Transport [MESH] |Receptor, Transforming Growth Factor-beta Type II [MESH] |Receptors, Transforming Growth Factor beta/genetics/metabolism [MESH] |Signal Transduction [MESH] |Skin Neoplasms/*immunology/pathology/therapy [MESH] |T-Lymphocytes, Regulatory/*physiology [MESH] |Transcriptional Activation [MESH] |Transforming Growth Factor beta/*physiology [MESH] |Tumor Escape [MESH]Membrane-organizing protein moesin controls Treg differentiation and a(epmc).pdf DeepDyve Pubget Overpricing