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10.1172/JCI88442 http://scihub22266oqcxt.onion/10.1172/JCI88442 C5373862!5373862 !28263189     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28263189 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2017 ; 127 (4 ): 1271-1283 Nephropedia Template TP {{tp|p=28263189 |t=2017. CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus |pdf=|usr=}}{{28263189 }} gab.com Text CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28263189 #FOAvip Genetic variations in the ITGAM gene (encoding CD11b) strongly associate with risk for systemic lupus erythematosus (SLE). Here we have shown that 3 nonsynonymous ITGAM variants that produce defective CD11b associate with elevated levels of type I interferon (IFN-I) in lupus, suggesting a direct link between reduced CD11b activity and the chronically increased inflammatory status in patients. Treatment with the small-molecule CD11b agonist LA1 led to partial integrin activation, reduced IFN-I responses in WT but not CD11b-deficient mice, and protected lupus-prone MRL/Lpr mice from end-organ injury. CD11b activation reduced TLR-dependent proinflammatory signaling in leukocytes and suppressed IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pathway. TLR-stimulated macrophages from CD11B SNP carriers showed increased basal expression of IFN regulatory factor 7 (IRF7) and IFN-?, as well as increased nuclear exclusion of FOXO3, which was suppressed by LA1-dependent activation of CD11b. This suggests that pharmacologic activation of CD11b could be a potential mechanism for developing SLE therapeutics. Twit Text FOAVip CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28263189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28263189 #FOAvip English Wikipedia <ref>{{Cite pmid|28263189 }}</ref> CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus #MMPMID28263189 Faridi MH ; Khan SQ ; Zhao W ; Lee HW ; Altintas MM ; Zhang K ; Kumar V ; Armstrong AR ; Carmona-Rivera C ; Dorschner JM ; Schnaith AM ; Li X ; Ghodke-Puranik Y ; Moore E ; Purmalek M ; Irizarry-Caro J ; Zhang T ; Day R ; Stoub D ; Hoffmann V ; Khaliqdina SJ ; Bhargava P ; Santander AM ; Torroella-Kouri M ; Issac B ; Cimbaluk DJ ; Zloza A ; Prabhakar R ; Deep S ; Jolly M ; Koh KH ; Reichner JS ; Bradshaw EM ; Chen J ; Moita LF ; Yuen PS ; Li Tsai W ; Singh B ; Reiser J ; Nath SK ; Niewold TB ; Vazquez-Padron RI ; Kaplan MJ ; Gupta V J Clin Invest 2017[Apr]; 127 (4 ): 1271-1283 PMID28263189 show ga Genetic variations in the ITGAM gene (encoding CD11b) strongly associate with risk for systemic lupus erythematosus (SLE). Here we have shown that 3 nonsynonymous ITGAM variants that produce defective CD11b associate with elevated levels of type I interferon (IFN-I) in lupus, suggesting a direct link between reduced CD11b activity and the chronically increased inflammatory status in patients. Treatment with the small-molecule CD11b agonist LA1 led to partial integrin activation, reduced IFN-I responses in WT but not CD11b-deficient mice, and protected lupus-prone MRL/Lpr mice from end-organ injury. CD11b activation reduced TLR-dependent proinflammatory signaling in leukocytes and suppressed IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pathway. TLR-stimulated macrophages from CD11B SNP carriers showed increased basal expression of IFN regulatory factor 7 (IRF7) and IFN-?, as well as increased nuclear exclusion of FOXO3, which was suppressed by LA1-dependent activation of CD11b. This suggests that pharmacologic activation of CD11b could be a potential mechanism for developing SLE therapeutics. |Animals [MESH] |CD11b Antigen/genetics/*immunology [MESH] |Female [MESH] |Forkhead Box Protein O3/genetics/immunology [MESH] |Humans [MESH] |Interferon Regulatory Factor-3/genetics/immunology [MESH] |Interferon Regulatory Factor-7/genetics/immunology [MESH] |Interferon Type I/genetics/immunology [MESH] |Lupus Erythematosus, Systemic/genetics/*immunology/pathology [MESH] |Macrophages/*immunology/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred MRL lpr [MESH] |Polymorphism, Single Nucleotide [MESH] |Proto-Oncogene Proteins c-akt/genetics/immunology [MESH]CD11b activation suppresses TLR-dependent inflammation and autoimmunit(epmc).pdf DeepDyve Pubget Overpricing