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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Neurol+Med+Chir+(Tokyo) 2017 ; 57 (3): 136-43 Nephropedia Template TP
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Leukoaraiosis is Associated with Worse Short-Term Functional and Cognitive Recovery after Minor Stroke #MMPMID28190826
ZHANG Z; REN W; SHAO B; XU H; CHENG J; WANG Q; GU Y; ZHU B; HE J
Neurol Med Chir (Tokyo) 2017[Mar]; 57 (3): 136-43 PMID28190826show ga
Whether leukoaraiosis burden retards short-term recovery after minor stroke is unclear. We investigated the association between leukoaraiosis and early recovery of neurological function after a first minor ischemic stroke in 217 acute stroke patients (National Institutes of Health Stroke Scale (NIHSS) score ?5). Leukoaraiosis severity was graded according to the Fazekas scale and categorized into none to mild (0?2; n = 143) or severe (3?6; n = 74) groups. NIHSS and Minimum Mental State Examination (MMSE) were assessed at baseline and at 30 days. Univariate analysis revealed that the severe leukoaraiosis group was older in age (P < 0.001) and had fewer low MMSE patients than non-mild group at baseline (39.1% vs 55.9%, P = 0.003). However, the MMSE improved in none to mild group but not in the severe group at 30-day (15.4% vs 36.5%, P < 0.001). At 30-day, the severe leukoaraiosis group had higher NIHSS scores than the none-mild group (P = 0.04). Multiple linear regression analyses demonstrated that leukoaraiosis severity and admission NIHSS were independently associated with the NIHSS score on day 30 (P = 0.034, 95% CI 0.004?0.091 and P = 0.001, 95% CI 0.011?0.04). Binary regression analyses showed that leukoaraiosis severity and admission MMSE were significantly associated with MMSE (dichotomized) at 30-day (OR 2.1, P < 0.01, 95% CI 1.7?2.6 and OR 5.1, P < 0.01, 95% CI 2.1?12.8). Leukoaraiosis burden is an independent predictor of worse short-term functional and cognitive recovery after a minor ischemic stroke.