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2017 ; 57
(3
): 136-143
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Leukoaraiosis is Associated with Worse Short-Term Functional and Cognitive
Recovery after Minor Stroke
#MMPMID28190826
Zhang Z
; Ren W
; Shao B
; Xu H
; Cheng J
; Wang Q
; Gu Y
; Zhu B
; He J
Neurol Med Chir (Tokyo)
2017[Mar]; 57
(3
): 136-143
PMID28190826
show ga
Whether leukoaraiosis burden retards short-term recovery after minor stroke is
unclear. We investigated the association between leukoaraiosis and early recovery
of neurological function after a first minor ischemic stroke in 217 acute stroke
patients (National Institutes of Health Stroke Scale (NIHSS) score ?5).
Leukoaraiosis severity was graded according to the Fazekas scale and categorized
into none to mild (0-2; n = 143) or severe (3-6; n = 74) groups. NIHSS and
Minimum Mental State Examination (MMSE) were assessed at baseline and at 30 days.
Univariate analysis revealed that the severe leukoaraiosis group was older in age
(P < 0.001) and had fewer low MMSE patients than non-mild group at baseline
(39.1% vs 55.9%, P = 0.003). However, the MMSE improved in none to mild group but
not in the severe group at 30-day (15.4% vs 36.5%, P < 0.001). At 30-day, the
severe leukoaraiosis group had higher NIHSS scores than the none-mild group (P =
0.04). Multiple linear regression analyses demonstrated that leukoaraiosis
severity and admission NIHSS were independently associated with the NIHSS score
on day 30 (P = 0.034, 95% CI 0.004-0.091 and P = 0.001, 95% CI 0.011-0.04).
Binary regression analyses showed that leukoaraiosis severity and admission MMSE
were significantly associated with MMSE (dichotomized) at 30-day (OR 2.1, P <
0.01, 95% CI 1.7-2.6 and OR 5.1, P < 0.01, 95% CI 2.1-12.8). Leukoaraiosis burden
is an independent predictor of worse short-term functional and cognitive recovery
after a minor ischemic stroke.