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10.1371/journal.pcbi.1005433 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1005433 C5373631!5373631 !28301477     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28301477 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Comput+Biol 2017 ; 13 (3 ): e1005433 Nephropedia Template TP {{tp|p=28301477 |t=2017. Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability |pdf=|usr=}}{{28301477 }} gab.com Text Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=28301477 #FOAvip Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin cytoskeleton in the foot processes. We determined how imbalances in regulation of actin cytoskeletal dynamics could result in pathological morphology. We obtained 3-D electron microscopy images of podocytes and used quantitative features to build dynamical models to investigate how regulation of actin dynamics within foot processes controls local morphology. We find that imbalances in regulation of actin bundling lead to chaotic spatial patterns that could impair the foot process morphology. Simulation results are consistent with experimental observations for cytoskeletal reconfiguration through dysregulated RhoA or Rac1, and they predict compensatory mechanisms for biochemical stability. We conclude that podocyte morphology, optimized for filtration, is intrinsically fragile, whereby local transient biochemical imbalances may lead to permanent morphological changes associated with pathophysiology. Twit Text FOAVip Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=28301477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28301477 #FOAvip English Wikipedia <ref>{{Cite pmid|28301477 }}</ref> Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability #MMPMID28301477 Falkenberg CV ; Azeloglu EU ; Stothers M ; Deerinck TJ ; Chen Y ; He JC ; Ellisman MH ; Hone JC ; Iyengar R ; Loew LM PLoS Comput Biol 2017[Mar]; 13 (3 ): e1005433 PMID28301477 show ga Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin cytoskeleton in the foot processes. We determined how imbalances in regulation of actin cytoskeletal dynamics could result in pathological morphology. We obtained 3-D electron microscopy images of podocytes and used quantitative features to build dynamical models to investigate how regulation of actin dynamics within foot processes controls local morphology. We find that imbalances in regulation of actin bundling lead to chaotic spatial patterns that could impair the foot process morphology. Simulation results are consistent with experimental observations for cytoskeletal reconfiguration through dysregulated RhoA or Rac1, and they predict compensatory mechanisms for biochemical stability. We conclude that podocyte morphology, optimized for filtration, is intrinsically fragile, whereby local transient biochemical imbalances may lead to permanent morphological changes associated with pathophysiology. |*Models, Biological [MESH] |Actin Cytoskeleton/*pathology/*physiology [MESH] |Cell Polarity [MESH] |Cell Size [MESH] |Cell Surface Extensions/*pathology/physiology [MESH] |Cells, Cultured [MESH] |Computer Simulation [MESH] |Humans [MESH] |Nonlinear Dynamics [MESH] |Podocytes/*pathology/*physiology [MESH]Fragility of foot process morphology in kidney podocytes arises from c(epmc).pdf DeepDyve Pubget Overpricing