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10.1681/ASN.2016070734 http://scihub22266oqcxt.onion/10.1681/ASN.2016070734 C5373463!5373463!28255001     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2017 ; 28 (4): 1040-9 Nephropedia Template TP {{tp|p=28255001|t=2017. Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update |pdf=|usr=}}{{28255001}} gab.com Text Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28255001 #FOAvip The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular volume homeostasis and blood pressure through complex mechanisms. Apart from the well known systemic RAS, occurrence of a local RAS has been documented in multiple tissues, including the kidney. A large body of recent evidence from pharmacologic and genetic studies, particularly those using various transgenic approaches to manipulate intrarenal levels of RAS components, has established the important role of intrarenal RAS in hypertension. Recent studies have also begun to unravel the molecular mechanisms that govern intrarenal RAS activity. This local system is under the control of complex regulatory networks consisting of positive regulators of (pro)renin receptor, Wnt/?-catenin signaling, and PGE2/PGE2 receptor EP4 subtype, and negative regulators of Klotho, vitamin D receptor, and liver X receptors. This review highlights recent advances in defining the regulation and function of intrarenal RAS as a unique entity separate from systemic angiotensin II generation. Twit Text FOAVip Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28255001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28255001 #FOAvip English Wikipedia <ref>{{Cite pmid|28255001}}</ref> Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update #MMPMID28255001 Yang T; Xu C J Am Soc Nephrol 2017[Apr]; 28 (4): 1040-9 PMID28255001show ga The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular volume homeostasis and blood pressure through complex mechanisms. Apart from the well known systemic RAS, occurrence of a local RAS has been documented in multiple tissues, including the kidney. A large body of recent evidence from pharmacologic and genetic studies, particularly those using various transgenic approaches to manipulate intrarenal levels of RAS components, has established the important role of intrarenal RAS in hypertension. Recent studies have also begun to unravel the molecular mechanisms that govern intrarenal RAS activity. This local system is under the control of complex regulatory networks consisting of positive regulators of (pro)renin receptor, Wnt/?-catenin signaling, and PGE2/PGE2 receptor EP4 subtype, and negative regulators of Klotho, vitamin D receptor, and liver X receptors. This review highlights recent advances in defining the regulation and function of intrarenal RAS as a unique entity separate from systemic angiotensin II generation. äPhysiology and Pathophysiology of the Intrarenal Renin-Angiotensin Sys(epmc).pdf DeepDyve Pubget Overpricing