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10.1681/ASN.2016060666 http://scihub22266oqcxt.onion/10.1681/ASN.2016060666 C5373460!5373460!28143897     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2017 ; 28 (4): 1023-39 Nephropedia Template TP {{tp|p=28143897|t=2017. Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment |pdf=|usr=}}{{28143897}} gab.com Text Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28143897 #FOAvip An absolute, supraphysiologic elevation in GFR is observed early in the natural history in 10%?67% and 6%?73% of patients with type 1 and type 2 diabetes, respectively. Moreover, at the single-nephron level, diabetes-related renal hemodynamic alterations?as an adaptation to reduction in functional nephron mass and/or in response to prevailing metabolic and (neuro)hormonal stimuli?increase glomerular hydraulic pressure and transcapillary convective flux of ultrafiltrate and macromolecules. This phenomenon, known as glomerular hyperfiltration, classically has been hypothesized to predispose to irreversible nephron damage, thereby contributing to initiation and progression of kidney disease in diabetes. However, dedicated studies with appropriate diagnostic measures and clinically relevant end points are warranted to confirm this assumption. In this review, we summarize the hitherto proposed mechanisms involved in diabetic hyperfiltration, focusing on ultrastructural, vascular, and tubular factors. Furthermore, we review available evidence on the clinical significance of hyperfiltration in diabetes and discuss currently available and emerging interventions that may attenuate this renal hemodynamic abnormality. The revived interest in glomerular hyperfiltration as a prognostic and pathophysiologic factor in diabetes may lead to improved and timely detection of (progressive) kidney disease, and could provide new therapeutic opportunities in alleviating the renal burden in this population. Twit Text FOAVip Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28143897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28143897 #FOAvip English Wikipedia <ref>{{Cite pmid|28143897}}</ref> Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment #MMPMID28143897 Tonneijck L; Muskiet MH; Smits MM; van Bommel EJ; Heerspink HJ; van Raalte DH; Joles JA J Am Soc Nephrol 2017[Apr]; 28 (4): 1023-39 PMID28143897show ga An absolute, supraphysiologic elevation in GFR is observed early in the natural history in 10%?67% and 6%?73% of patients with type 1 and type 2 diabetes, respectively. Moreover, at the single-nephron level, diabetes-related renal hemodynamic alterations?as an adaptation to reduction in functional nephron mass and/or in response to prevailing metabolic and (neuro)hormonal stimuli?increase glomerular hydraulic pressure and transcapillary convective flux of ultrafiltrate and macromolecules. This phenomenon, known as glomerular hyperfiltration, classically has been hypothesized to predispose to irreversible nephron damage, thereby contributing to initiation and progression of kidney disease in diabetes. However, dedicated studies with appropriate diagnostic measures and clinically relevant end points are warranted to confirm this assumption. In this review, we summarize the hitherto proposed mechanisms involved in diabetic hyperfiltration, focusing on ultrastructural, vascular, and tubular factors. Furthermore, we review available evidence on the clinical significance of hyperfiltration in diabetes and discuss currently available and emerging interventions that may attenuate this renal hemodynamic abnormality. The revived interest in glomerular hyperfiltration as a prognostic and pathophysiologic factor in diabetes may lead to improved and timely detection of (progressive) kidney disease, and could provide new therapeutic opportunities in alleviating the renal burden in this population. äGlomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significa(epmc).pdf DeepDyve Pubget Overpricing