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10.1681/ASN.2016040401 http://scihub22266oqcxt.onion/10.1681/ASN.2016040401 C5373449!5373449!28122946     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2017 ; 28 (4): 1239-46 Nephropedia Template TP {{tp|p=28122946|t=2017. Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults |pdf=|usr=}}{{28122946}} gab.com Text Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28122946 #FOAvip Within monocytes, 1,25-dihydroxyvitamin D [1,25(OH)2D] is important for production of cathelicidins, which in turn, are critical for antibacterial action. Fibroblast growth factor 23 (FGF23) decreases 1,25(OH)2D production and thus, could increase infection risk. We examined this possibility in 3141 community-dwelling adults ages ?65 years old at baseline in the Cardiovascular Health Study using Cox proportional hazards models to examine the association between FGF23 concentrations and first infection-related hospitalizations and determine whether associations differed by the presence of CKD (eGFR<60 ml/min per 1.73 m2 [n=832] or urine albumin-to-creatinine ratio >30 mg/g [n=577]). MeanąSD age of participants was 78ą5 years old, 60% of participants were women, and the median plasma FGF23 concentration was 70 (interquartile range, 53?99) relative units per milliliter. In fully adjusted models, higher FGF23 concentrations associated with higher risk of first infection-related hospitalization (hazard ratio [HR], 1.11; 95% confidence interval [95% CI], 1.03 to 1.20 per doubling of FGF23) during a median follow-up of 8.6 years. In participants with or without CKD (defined by eGFR), FGF23 concentration associated with first infection-related hospitalization with HRs of 1.24 (95% CI, 1.08 to 1.42) and 1.06 (95% CI, 0.97 to 1.17) per doubling of FGF23, respectively (P=0.13 for interaction). Associations did not differ between groups when stratified by urine albumin-to-creatinine ratio. In sensitivity analyses, the addition of serum calcium, phosphorus, 25-hydroxyvitamin D, intact parathyroid hormone, and 24,25-dihydroxyvitamin D did not meaningfully change the estimates. In conclusion, in community-dwelling older adults, higher plasma FGF23 concentrations independently associated with the risk of first infection-related hospitalization. Twit Text FOAVip Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28122946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28122946 #FOAvip English Wikipedia <ref>{{Cite pmid|28122946}}</ref> Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults #MMPMID28122946 Nowak KL; Bartz TM; Dalrymple L; de Boer IH; Kestenbaum B; Shlipak MG; Garimella PS; Ix JH; Chonchol M J Am Soc Nephrol 2017[Apr]; 28 (4): 1239-46 PMID28122946show ga Within monocytes, 1,25-dihydroxyvitamin D [1,25(OH)2D] is important for production of cathelicidins, which in turn, are critical for antibacterial action. Fibroblast growth factor 23 (FGF23) decreases 1,25(OH)2D production and thus, could increase infection risk. We examined this possibility in 3141 community-dwelling adults ages ?65 years old at baseline in the Cardiovascular Health Study using Cox proportional hazards models to examine the association between FGF23 concentrations and first infection-related hospitalizations and determine whether associations differed by the presence of CKD (eGFR<60 ml/min per 1.73 m2 [n=832] or urine albumin-to-creatinine ratio >30 mg/g [n=577]). MeanąSD age of participants was 78ą5 years old, 60% of participants were women, and the median plasma FGF23 concentration was 70 (interquartile range, 53?99) relative units per milliliter. In fully adjusted models, higher FGF23 concentrations associated with higher risk of first infection-related hospitalization (hazard ratio [HR], 1.11; 95% confidence interval [95% CI], 1.03 to 1.20 per doubling of FGF23) during a median follow-up of 8.6 years. In participants with or without CKD (defined by eGFR), FGF23 concentration associated with first infection-related hospitalization with HRs of 1.24 (95% CI, 1.08 to 1.42) and 1.06 (95% CI, 0.97 to 1.17) per doubling of FGF23, respectively (P=0.13 for interaction). Associations did not differ between groups when stratified by urine albumin-to-creatinine ratio. In sensitivity analyses, the addition of serum calcium, phosphorus, 25-hydroxyvitamin D, intact parathyroid hormone, and 24,25-dihydroxyvitamin D did not meaningfully change the estimates. In conclusion, in community-dwelling older adults, higher plasma FGF23 concentrations independently associated with the risk of first infection-related hospitalization. äFibroblast Growth Factor 23 and the Risk of Infection-Related Hospital(epmc).pdf DeepDyve Pubget Overpricing