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10.1681/ASN.2016030378

http://scihub22266oqcxt.onion/10.1681/ASN.2016030378
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C5373448!5373448!27909047
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suck abstract from ncbi


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pmid27909047      J+Am+Soc+Nephrol 2017 ; 28 (4): 1259-68
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  • Exercise in Patients on Dialysis: A Multicenter, Randomized Clinical Trial #MMPMID27909047
  • Manfredini F; Mallamaci F; D?Arrigo G; Baggetta R; Bolignano D; Torino C; Lamberti N; Bertoli S; Ciurlino D; Rocca-Rey L; Barillą A; Battaglia Y; Rapaną RM; Zuccalą A; Bonanno G; Fatuzzo P; Rapisarda F; Rastelli S; Fabrizi F; Messa P; De Paola L; Lombardi L; Cupisti A; Fuiano G; Lucisano G; Summaria C; Felisatti M; Pozzato E; Malagoni AM; Castellino P; Aucella F; Abd ElHafeez S; Provenzano PF; Tripepi G; Catizone L; Zoccali C
  • J Am Soc Nephrol 2017[Apr]; 28 (4): 1259-68 PMID27909047show ga
  • Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted the Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial to test whether a simple, personalized walking exercise program at home, managed by dialysis staff, improves functional status in adult patients on dialysis. The main study outcomes included change in physical performance at 6 months, assessed by the 6-minute walking test and the five times sit-to-stand test, and in quality of life, assessed by the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. We randomized 296 patients to normal physical activity (control; n=145) or walking exercise (n=151); 227 patients (exercise n=104; control n=123) repeated the 6-month evaluations. The distance covered during the 6-minute walking test improved in the exercise group (mean distance±SD: baseline, 328±96 m; 6 months, 367±113 m) but not in the control group (baseline, 321±107 m; 6 months, 324±116 m; P<0.001 between groups). Similarly, the five times sit-to-stand test time improved in the exercise group (mean time±SD: baseline, 20.5±6.0 seconds; 6 months, 18.2±5.7 seconds) but not in the control group (baseline, 20.9±5.8 seconds; 6 months, 20.2±6.4 seconds; P=0.001 between groups). The cognitive function score (P=0.04) and quality of social interaction score (P=0.01) in the kidney disease component of the KDQOL-SF improved significantly in the exercise arm compared with the control arm. Hence, a simple, personalized, home-based, low-intensity exercise program managed by dialysis staff may improve physical performance and quality of life in patients on dialysis.
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