Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1681/ASN.2015101169 http://scihub22266oqcxt.onion/10.1681/ASN.2015101169 C5373439!5373439!27837150     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2017 ; 28 (4): 1188-99 Nephropedia Template TP {{tp|p=27837150|t=2017. IL-6 Trans?Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane |pdf=|usr=}}{{27837150}} gab.com Text IL-6 Trans Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27837150 #FOAvip Vascular endothelial growth factor (VEGF) is implicated in the peritoneal membrane remodeling that limits ultrafiltration in patients on peritoneal dialysis (PD). Although the exact mechanism of VEGF induction in PD is unclear, VEGF concentrations in drained dialysate correlate with IL-6 levels, suggesting a link between these cytokines. Human peritoneal mesothelial cells (HPMCs), the main source of IL-6 and VEGF in the peritoneum, do not bear the cognate IL-6 receptor and are thus unable to respond to classic IL-6 receptor signaling. Here, we investigated whether VEGF release by HPMCs is controlled by IL-6 in combination with its soluble receptor (IL-6 trans?signaling). Although treatment with either IL-6 or soluble IL-6 receptor (sIL-6R) alone had no effect on VEGF production, stimulation of HPMCs with IL-6 in combination with sIL-6R promoted VEGF expression and secretion through a transcriptional mechanism involving STAT3 and SP4. Conditioned medium from HPMCs cultured with IL-6 and sIL-6R promoted angiogenic endothelial tube formation, which could be blocked by silencing SP4. In vivo, induction of peritoneal inflammation in wild-type and IL-6?deficient mice showed IL-6 involvement in the control of Sp4 and Vegf expression and new vessel formation, confirming the role of IL-6 trans?signaling in these processes. Taken together, these findings identify a novel mechanism linking IL-6 trans?signaling and angiogenesis in the peritoneal membrane. Twit Text FOAVip IL-6 Trans Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27837150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27837150 #FOAvip English Wikipedia <ref>{{Cite pmid|27837150}}</ref> IL-6 Trans?Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane #MMPMID27837150 Catar R; Witowski J; Zhu N; Lücht C; Derrac Soria A; Uceda Fernandez J; Chen L; Jones SA; Fielding CA; Rudolf A; Topley N; Dragun D; Jörres A J Am Soc Nephrol 2017[Apr]; 28 (4): 1188-99 PMID27837150show ga Vascular endothelial growth factor (VEGF) is implicated in the peritoneal membrane remodeling that limits ultrafiltration in patients on peritoneal dialysis (PD). Although the exact mechanism of VEGF induction in PD is unclear, VEGF concentrations in drained dialysate correlate with IL-6 levels, suggesting a link between these cytokines. Human peritoneal mesothelial cells (HPMCs), the main source of IL-6 and VEGF in the peritoneum, do not bear the cognate IL-6 receptor and are thus unable to respond to classic IL-6 receptor signaling. Here, we investigated whether VEGF release by HPMCs is controlled by IL-6 in combination with its soluble receptor (IL-6 trans?signaling). Although treatment with either IL-6 or soluble IL-6 receptor (sIL-6R) alone had no effect on VEGF production, stimulation of HPMCs with IL-6 in combination with sIL-6R promoted VEGF expression and secretion through a transcriptional mechanism involving STAT3 and SP4. Conditioned medium from HPMCs cultured with IL-6 and sIL-6R promoted angiogenic endothelial tube formation, which could be blocked by silencing SP4. In vivo, induction of peritoneal inflammation in wild-type and IL-6?deficient mice showed IL-6 involvement in the control of Sp4 and Vegf expression and new vessel formation, confirming the role of IL-6 trans?signaling in these processes. Taken together, these findings identify a novel mechanism linking IL-6 trans?signaling and angiogenesis in the peritoneal membrane. äIL-6 Trans?Signaling Links Inflammation with Angiogenesis in the Perit(epmc).pdf DeepDyve Pubget Overpricing