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10.1073/pnas.1700172114 http://scihub22266oqcxt.onion/10.1073/pnas.1700172114 C5373383!5373383!28270609     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (12): 3181-5 Nephropedia Template TP {{tp|p=28270609|t=2017. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis |pdf=|usr=}}{{28270609}} gab.com Text Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28270609 #FOAvip Nonalcoholic fatty liver disease (NAFLD) is a common chronic hepatic disease, eventually leading to liver fibrosis and cirrhosis. Currently, no effective treatment is available. This study reports the role of cytochrome P450 omega-hydroxylase 4A14 (CYP4A14) in the development and progression of NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, high-fat diet (HFD)- and methionine and choline-deficient diet (MCD)-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced nonalcoholic steatohepatitis (NASH). CYP4A14 may represent a therapeutic target for the treatment of NAFLD. Twit Text FOAVip Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28270609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28270609 #FOAvip English Wikipedia <ref>{{Cite pmid|28270609}}</ref> Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis #MMPMID28270609 Zhang X; Li S; Zhou Y; Su W; Ruan X; Wang B; Zheng F; Warner M; Gustafsson JÅ; Guan Y Proc Natl Acad Sci U S A 2017[Mar]; 114 (12): 3181-5 PMID28270609show ga Nonalcoholic fatty liver disease (NAFLD) is a common chronic hepatic disease, eventually leading to liver fibrosis and cirrhosis. Currently, no effective treatment is available. This study reports the role of cytochrome P450 omega-hydroxylase 4A14 (CYP4A14) in the development and progression of NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, high-fat diet (HFD)- and methionine and choline-deficient diet (MCD)-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced nonalcoholic steatohepatitis (NASH). CYP4A14 may represent a therapeutic target for the treatment of NAFLD. äAblation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hep(epmc).pdf DeepDyve Pubget Overpricing