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10.1073/pnas.1612906114 http://scihub22266oqcxt.onion/10.1073/pnas.1612906114 C5373350!5373350 !28265064     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28265064 &cmd=llinks): Failed to open stream: HTTP request failed! 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Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors |pdf=|usr=}}{{28265064 }} gab.com Text Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28265064 #FOAvip Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models designed to recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These in vitro models, featuring biomimetic compositions, architectures, and functions, are expected to replace the conventional planar, static cell cultures and bridge the gap between the currently used preclinical animal models and the human body. Multiple organoid models may be further connected together through the microfluidics in a similar manner in which they are arranged in vivo, providing the capability to analyze multiorgan interactions. Although a wide variety of human organ-on-a-chip models have been created, there are limited efforts on the integration of multisensor systems. However, in situ continual measuring is critical in precise assessment of the microenvironment parameters and the dynamic responses of the organs to pharmaceutical compounds over extended periods of time. In addition, automated and noninvasive capability is strongly desired for long-term monitoring. Here, we report a fully integrated modular physical, biochemical, and optical sensing platform through a fluidics-routing breadboard, which operates organ-on-a-chip units in a continual, dynamic, and automated manner. We believe that this platform technology has paved a potential avenue to promote the performance of current organ-on-a-chip models in drug screening by integrating a multitude of real-time sensors to achieve automated in situ monitoring of biophysical and biochemical parameters. Twit Text FOAVip Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28265064 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28265064 #FOAvip English Wikipedia <ref>{{Cite pmid|28265064 }}</ref> Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors #MMPMID28265064 Zhang YS ; Aleman J ; Shin SR ; Kilic T ; Kim D ; Mousavi Shaegh SA ; Massa S ; Riahi R ; Chae S ; Hu N ; Avci H ; Zhang W ; Silvestri A ; Sanati Nezhad A ; Manbohi A ; De Ferrari F ; Polini A ; Calzone G ; Shaikh N ; Alerasool P ; Budina E ; Kang J ; Bhise N ; Ribas J ; Pourmand A ; Skardal A ; Shupe T ; Bishop CE ; Dokmeci MR ; Atala A ; Khademhosseini A Proc Natl Acad Sci U S A 2017[Mar]; 114 (12 ): E2293-E2302 PMID28265064 show ga Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models designed to recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These in vitro models, featuring biomimetic compositions, architectures, and functions, are expected to replace the conventional planar, static cell cultures and bridge the gap between the currently used preclinical animal models and the human body. Multiple organoid models may be further connected together through the microfluidics in a similar manner in which they are arranged in vivo, providing the capability to analyze multiorgan interactions. Although a wide variety of human organ-on-a-chip models have been created, there are limited efforts on the integration of multisensor systems. However, in situ continual measuring is critical in precise assessment of the microenvironment parameters and the dynamic responses of the organs to pharmaceutical compounds over extended periods of time. In addition, automated and noninvasive capability is strongly desired for long-term monitoring. Here, we report a fully integrated modular physical, biochemical, and optical sensing platform through a fluidics-routing breadboard, which operates organ-on-a-chip units in a continual, dynamic, and automated manner. We believe that this platform technology has paved a potential avenue to promote the performance of current organ-on-a-chip models in drug screening by integrating a multitude of real-time sensors to achieve automated in situ monitoring of biophysical and biochemical parameters. |Automation/instrumentation/*methods [MESH] |Biosensing Techniques/instrumentation/*methods [MESH] |Drug Evaluation, Preclinical/instrumentation/*methods [MESH] |Heart/physiology [MESH] |Humans [MESH] |Liver/chemistry/physiology [MESH] |Microfluidics [MESH] |Models, Biological [MESH] |Myocardium [MESH]Multisensor-integrated organs-on-chips platform for automated and cont(epmc).pdf DeepDyve Pubget Overpricing