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10.1097/MCC.0000000000000386 http://scihub22266oqcxt.onion/10.1097/MCC.0000000000000386 C5373099!5373099!28092310     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28092310&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Crit+Care 2017 ; 23 (2): 143-8 Nephropedia Template TP {{tp|p=28092310|t=2017. New insights into the gut as the driver of critical illness and organ failure |pdf=|usr=}}{{28092310}} gab.com Text New insights into the gut as the driver of critical illness and organ failure JO: Curr Opin Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=28092310 #FOAvip Purpose of review: The gut has long been hypothesized to be the ?motor? of multiple organ dysfunction syndrome (MODS). This review serves as an update on new data elucidating the role of the gut as the propagator of organ failure in critical illness. Recent findings: Under basal conditions, the gut absorbs nutrients and serves as a barrier that prevents approximately 40 trillion intraluminal microbes and their products from causing host injury. However, in critical illness, gut integrity is disrupted with hyperpermeability and increased epithelial apoptosis, allowing contamination of extraluminal sites that are ordinarily sterile. These alterations in gut integrity are further exacerbated in the setting of pre-existing co-morbidities. The normally commensal microflora is also altered in critical illness, with increases in microbial virulence and decreases in diversity, which leads to further pathologic responses within the host. Summary: All components of the gut are adversely impacted by critical illness. Gut injury can not only propagate local damage, but can also cause distant injury and organ failure. Understanding how the multifaceted components of the gut interact and how these are perturbed in critical illness may play an important role in turning off the ?motor? of MODS in the future. Twit Text FOAVip New insights into the gut as the driver of critical illness and organ failure ????Curr Opin Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=28092310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28092310 #FOAvip English Wikipedia <ref>{{Cite pmid|28092310}}</ref> New insights into the gut as the driver of critical illness and organ failure #MMPMID28092310 Meng M; Klingensmith NJ; Coopersmith CM Curr Opin Crit Care 2017[Apr]; 23 (2): 143-8 PMID28092310show ga Purpose of review: The gut has long been hypothesized to be the ?motor? of multiple organ dysfunction syndrome (MODS). This review serves as an update on new data elucidating the role of the gut as the propagator of organ failure in critical illness. Recent findings: Under basal conditions, the gut absorbs nutrients and serves as a barrier that prevents approximately 40 trillion intraluminal microbes and their products from causing host injury. However, in critical illness, gut integrity is disrupted with hyperpermeability and increased epithelial apoptosis, allowing contamination of extraluminal sites that are ordinarily sterile. These alterations in gut integrity are further exacerbated in the setting of pre-existing co-morbidities. The normally commensal microflora is also altered in critical illness, with increases in microbial virulence and decreases in diversity, which leads to further pathologic responses within the host. Summary: All components of the gut are adversely impacted by critical illness. Gut injury can not only propagate local damage, but can also cause distant injury and organ failure. Understanding how the multifaceted components of the gut interact and how these are perturbed in critical illness may play an important role in turning off the ?motor? of MODS in the future. äNew insights into the gut as the driver of critical illness and organ (epmc).pdf DeepDyve Pubget Overpricing