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10.3390/ijms18030595 http://scihub22266oqcxt.onion/10.3390/ijms18030595 C5372611!5372611 !28282921     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28282921 &cmd=llinks): Failed to open stream: HTTP request failed! 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Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants |pdf=|usr=}}{{28282921 }} gab.com Text Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28282921 #FOAvip In its soluble form, the extracellular matrix proteoglycan biglycan triggers the synthesis of the macrophage chemoattractants, chemokine (C-C motif) ligand CCL2 and CCL5 through selective utilization of Toll-like receptors (TLRs) and their adaptor molecules. However, the respective downstream signaling events resulting in biglycan-induced CCL2 and CCL5 production have not yet been defined. Here, we show that biglycan stimulates the production and activation of sphingosine kinase 1 (SphK1) in a TLR4- and Toll/interleukin (IL)-1R domain-containing adaptor inducing interferon (IFN)-? (TRIF)-dependent manner in murine primary macrophages. We provide genetic and pharmacological proof that SphK1 is a crucial downstream mediator of biglycan-triggered CCL2 and CCL5 mRNA and protein expression. This is selectively driven by biglycan/SphK1-dependent phosphorylation of the nuclear factor NF-?B p65 subunit, extracellular signal-regulated kinase (Erk)1/2 and p38 mitogen-activated protein kinases. Importantly, in vivo overexpression of soluble biglycan causes Sphk1-dependent enhancement of renal CCL2 and CCL5 and macrophage recruitment into the kidney. Our findings describe the crosstalk between biglycan- and SphK1-driven extracellular matrix- and lipid-signaling. Thus, SphK1 may represent a new target for therapeutic intervention in biglycan-evoked inflammatory conditions. Twit Text FOAVip Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28282921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28282921 #FOAvip English Wikipedia <ref>{{Cite pmid|28282921 }}</ref> Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants #MMPMID28282921 Hsieh LT ; Nastase MV ; Roedig H ; Zeng-Brouwers J ; Poluzzi C ; Schwalm S ; Fork C ; Tredup C ; Brandes RP ; Wygrecka M ; Huwiler A ; Pfeilschifter J ; Schaefer L Int J Mol Sci 2017[Mar]; 18 (3 ): ä PMID28282921 show ga In its soluble form, the extracellular matrix proteoglycan biglycan triggers the synthesis of the macrophage chemoattractants, chemokine (C-C motif) ligand CCL2 and CCL5 through selective utilization of Toll-like receptors (TLRs) and their adaptor molecules. However, the respective downstream signaling events resulting in biglycan-induced CCL2 and CCL5 production have not yet been defined. Here, we show that biglycan stimulates the production and activation of sphingosine kinase 1 (SphK1) in a TLR4- and Toll/interleukin (IL)-1R domain-containing adaptor inducing interferon (IFN)-? (TRIF)-dependent manner in murine primary macrophages. We provide genetic and pharmacological proof that SphK1 is a crucial downstream mediator of biglycan-triggered CCL2 and CCL5 mRNA and protein expression. This is selectively driven by biglycan/SphK1-dependent phosphorylation of the nuclear factor NF-?B p65 subunit, extracellular signal-regulated kinase (Erk)1/2 and p38 mitogen-activated protein kinases. Importantly, in vivo overexpression of soluble biglycan causes Sphk1-dependent enhancement of renal CCL2 and CCL5 and macrophage recruitment into the kidney. Our findings describe the crosstalk between biglycan- and SphK1-driven extracellular matrix- and lipid-signaling. Thus, SphK1 may represent a new target for therapeutic intervention in biglycan-evoked inflammatory conditions. |*MAP Kinase Signaling System [MESH] |Adaptor Proteins, Vesicular Transport/metabolism [MESH] |Animals [MESH] |Biglycan/*metabolism [MESH] |Cells, Cultured [MESH] |Chemokine CCL2/*metabolism [MESH] |Chemokine CCL5/*metabolism [MESH] |Extracellular Matrix/metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Macrophages/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mitogen-Activated Protein Kinase 1/metabolism [MESH] |Mitogen-Activated Protein Kinase 3/metabolism [MESH] |Phosphotransferases (Alcohol Group Acceptor)/*metabolism [MESH] |Toll-Like Receptor 4/metabolism [MESH] |Transcription Factor RelA/metabolism [MESH]Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the S(epmc).pdf DeepDyve Pubget Overpricing