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10.3390/ijms18030532 http://scihub22266oqcxt.onion/10.3390/ijms18030532 C5372548!5372548 !28257048     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28257048 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (3 ): ä Nephropedia Template TP {{tp|p=28257048 |t=2017. Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1? mRNA Expression in Malignant Melanoma Cells |pdf=|usr=}}{{28257048 }} gab.com Text Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1 mRNA Expression in Malignant Melanoma Cells JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28257048 #FOAvip Recent studies have shown that vanillin has anti-cancer, anti-mutagenic, and anti-metastatic activity; however, the precise molecular mechanism whereby vanillin inhibits metastasis and cancer progression is not fully elucidated. In this study, we examined whether vanillin has anti-cancer and anti-metastatic activities via inhibition of hypoxia-inducible factor-1? (HIF-1?) in A2058 and A375 human malignant melanoma cells. Immunoblotting and quantitative real time (RT)-PCR analysis revealed that vanillin down-regulates HIF-1? protein accumulation and the transcripts of HIF-1? target genes related to cancer metastasis including fibronectin 1 (FN1), lysyl oxidase-like 2 (LOXL2), and urokinase plasminogen activator receptor (uPAR). It was also found that vanillin significantly suppresses HIF-1? mRNA expression and de novo HIF-1? protein synthesis. To understand the suppressive mechanism of vanillin on HIF-1? expression, chromatin immunoprecipitation was performed. Consequently, it was found that vanillin causes inhibition of promoter occupancy by signal transducer and activator of transcription 3 (STAT3), but not nuclear factor-?B (NF-?B), on HIF1A. Furthermore, an in vitro migration assay revealed that the motility of melanoma cells stimulated by hypoxia was attenuated by vanillin treatment. In conclusion, we demonstrate that vanillin might be a potential anti-metastatic agent that suppresses metastatic gene expression and migration activity under hypoxia via the STAT3-HIF-1? signaling pathway. Twit Text FOAVip Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1 mRNA Expression in Malignant Melanoma Cells ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28257048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28257048 #FOAvip English Wikipedia <ref>{{Cite pmid|28257048 }}</ref> Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1? mRNA Expression in Malignant Melanoma Cells #MMPMID28257048 Park EJ ; Lee YM ; Oh TI ; Kim BM ; Lim BO ; Lim JH Int J Mol Sci 2017[Mar]; 18 (3 ): ä PMID28257048 show ga Recent studies have shown that vanillin has anti-cancer, anti-mutagenic, and anti-metastatic activity; however, the precise molecular mechanism whereby vanillin inhibits metastasis and cancer progression is not fully elucidated. In this study, we examined whether vanillin has anti-cancer and anti-metastatic activities via inhibition of hypoxia-inducible factor-1? (HIF-1?) in A2058 and A375 human malignant melanoma cells. Immunoblotting and quantitative real time (RT)-PCR analysis revealed that vanillin down-regulates HIF-1? protein accumulation and the transcripts of HIF-1? target genes related to cancer metastasis including fibronectin 1 (FN1), lysyl oxidase-like 2 (LOXL2), and urokinase plasminogen activator receptor (uPAR). It was also found that vanillin significantly suppresses HIF-1? mRNA expression and de novo HIF-1? protein synthesis. To understand the suppressive mechanism of vanillin on HIF-1? expression, chromatin immunoprecipitation was performed. Consequently, it was found that vanillin causes inhibition of promoter occupancy by signal transducer and activator of transcription 3 (STAT3), but not nuclear factor-?B (NF-?B), on HIF1A. Furthermore, an in vitro migration assay revealed that the motility of melanoma cells stimulated by hypoxia was attenuated by vanillin treatment. In conclusion, we demonstrate that vanillin might be a potential anti-metastatic agent that suppresses metastatic gene expression and migration activity under hypoxia via the STAT3-HIF-1? signaling pathway. |Benzaldehydes/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects [MESH] |Gene Expression Regulation, Neoplastic/*drug effects [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*genetics/metabolism [MESH] |Melanoma/*genetics/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |RNA, Messenger/genetics/metabolism [MESH] |STAT3 Transcription Factor/*metabolism [MESH]Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1? (epmc).pdf DeepDyve Pubget Overpricing