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10.1038/nmicrobiol.2016.199 http://scihub22266oqcxt.onion/10.1038/nmicrobiol.2016.199 C5372380!5372380 !27841852     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27841852 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Microbiol 2016 ; 2 (ä): 16199 Nephropedia Template TP {{tp|p=27841852 |t=2016. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability |pdf=|usr=}}{{27841852 }} gab.com Text An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27841852 #FOAvip The induction by vaccination of broadly neutralizing antibodies (bNAbs) capable of neutralizing various HIV-1 viral strains is challenging, but understanding how a subset of HIV-infected individuals develops bNAbs may guide immunization strategies. Here, we describe the isolation and characterization of the bNAb ACS202 from an elite neutralizer that recognizes a new, trimer-specific and cleavage-dependent epitope at the gp120-gp41 interface of the envelope glycoprotein (Env), involving the glycan N88 and the gp41 fusion peptide. In addition, an Env trimer, AMC011 SOSIP.v4.2, based on early virus isolates from the same elite neutralizer, was constructed, and its structure by cryo-electron microscopy at 6.2?Å resolution reveals a closed, pre-fusion conformation similar to that of the BG505 SOSIP.664 trimer. The availability of a native-like Env trimer and a bNAb from the same elite neutralizer provides the opportunity to design vaccination strategies aimed at generating similar bNAbs against a key functional site on HIV-1. Twit Text FOAVip An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27841852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27841852 #FOAvip English Wikipedia <ref>{{Cite pmid|27841852 }}</ref> An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability #MMPMID27841852 van Gils MJ ; van den Kerkhof TL ; Ozorowski G ; Cottrell CA ; Sok D ; Pauthner M ; Pallesen J ; de Val N ; Yasmeen A ; de Taeye SW ; Schorcht A ; Gumbs S ; Johanna I ; Saye-Francisco K ; Liang CH ; Landais E ; Nie X ; Pritchard LK ; Crispin M ; Kelsoe G ; Wilson IA ; Schuitemaker H ; Klasse PJ ; Moore JP ; Burton DR ; Ward AB ; Sanders RW Nat Microbiol 2016[Nov]; 2 (ä): 16199 PMID27841852 show ga The induction by vaccination of broadly neutralizing antibodies (bNAbs) capable of neutralizing various HIV-1 viral strains is challenging, but understanding how a subset of HIV-infected individuals develops bNAbs may guide immunization strategies. Here, we describe the isolation and characterization of the bNAb ACS202 from an elite neutralizer that recognizes a new, trimer-specific and cleavage-dependent epitope at the gp120-gp41 interface of the envelope glycoprotein (Env), involving the glycan N88 and the gp41 fusion peptide. In addition, an Env trimer, AMC011 SOSIP.v4.2, based on early virus isolates from the same elite neutralizer, was constructed, and its structure by cryo-electron microscopy at 6.2?Å resolution reveals a closed, pre-fusion conformation similar to that of the BG505 SOSIP.664 trimer. The availability of a native-like Env trimer and a bNAb from the same elite neutralizer provides the opportunity to design vaccination strategies aimed at generating similar bNAbs against a key functional site on HIV-1. |*HIV Long-Term Survivors [MESH] |Antibodies, Neutralizing/*immunology/isolation & purification [MESH] |Cryoelectron Microscopy [MESH] |Epitopes, B-Lymphocyte/immunology [MESH] |HIV Antibodies/*immunology/isolation & purification [MESH] |HIV Envelope Protein gp160/immunology/ultrastructure [MESH] |HIV Infections/*immunology [MESH]An HIV-1 antibody from an elite neutralizer implicates the fusion pept(epmc).pdf DeepDyve Pubget Overpricing