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10.1002/hep.28944 http://scihub22266oqcxt.onion/10.1002/hep.28944 C5372202!5372202!27862115     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hepatology 2017 ; 65 (3): 1026-37 Nephropedia Template TP {{tp|p=27862115|t=2017. Pediatric Acute Liver Failure of Undetermined Cause: A Research Workshop |pdf=|usr=}}{{27862115}} gab.com Text Pediatric Acute Liver Failure of Undetermined Cause: A Research Workshop JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=27862115 #FOAvip Pediatric Acute liver failure (PALF) is a potentially devastating condition which occurs in previously healthy children of all ages and frequently leads to a rapid clinical deterioration. An identified cause for liver injury is lacking in approximately 30% of cases. Children with undetermined diagnosis have lower spontaneous survival and higher rates of transplantation and death than other diagnostic groups. A single day workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases brought together clinicians and basic scientists to integrate aligned research findings and develop a foundation for new mechanistic studies and future treatment trials. The clinical phenotype of indeterminate PALF shares important similarities to the hyperinflammatory state characteristic of Hemophagocytic lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS). A failure of cytotoxic T cells to limit or contract inflammatory responses may propagate injury and lead to a local and systemic milieu that does not support normal hepatic regeneration. Evidence was presented that bone marrow (BM) derived Sinusoidal endothelial cell PROgenitor Cells (sprocs) play a vital role in hepatic regeneration. Overwhelming systemic inflammatory responses may suppress mobilization of BM sprocs and dampen hepatic recovery. Conclusion: Thus, experience gained through treatment trials of HLH and MAS in childhood may inform study design for therapy of PALF. Successful approaches to limiting neuro-inflammation through reduction of systemic inflammation and standardized neuroprotection protocols that limit glial injury could significantly improve intact survival. Finally, since PALF is a rare disease, investigative efforts must include broad multi-center collaboration and careful stewardship of biorepository specimens. Twit Text FOAVip Pediatric Acute Liver Failure of Undetermined Cause: A Research Workshop ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=27862115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27862115 #FOAvip English Wikipedia <ref>{{Cite pmid|27862115}}</ref> Pediatric Acute Liver Failure of Undetermined Cause: A Research Workshop #MMPMID27862115 Alonso EM; Horslen SP; Behrens EM; Doo E Hepatology 2017[Mar]; 65 (3): 1026-37 PMID27862115show ga Pediatric Acute liver failure (PALF) is a potentially devastating condition which occurs in previously healthy children of all ages and frequently leads to a rapid clinical deterioration. An identified cause for liver injury is lacking in approximately 30% of cases. Children with undetermined diagnosis have lower spontaneous survival and higher rates of transplantation and death than other diagnostic groups. A single day workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases brought together clinicians and basic scientists to integrate aligned research findings and develop a foundation for new mechanistic studies and future treatment trials. The clinical phenotype of indeterminate PALF shares important similarities to the hyperinflammatory state characteristic of Hemophagocytic lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS). A failure of cytotoxic T cells to limit or contract inflammatory responses may propagate injury and lead to a local and systemic milieu that does not support normal hepatic regeneration. Evidence was presented that bone marrow (BM) derived Sinusoidal endothelial cell PROgenitor Cells (sprocs) play a vital role in hepatic regeneration. Overwhelming systemic inflammatory responses may suppress mobilization of BM sprocs and dampen hepatic recovery. Conclusion: Thus, experience gained through treatment trials of HLH and MAS in childhood may inform study design for therapy of PALF. Successful approaches to limiting neuro-inflammation through reduction of systemic inflammation and standardized neuroprotection protocols that limit glial injury could significantly improve intact survival. Finally, since PALF is a rare disease, investigative efforts must include broad multi-center collaboration and careful stewardship of biorepository specimens. äPediatric Acute Liver Failure of Undetermined Cause: A Research Worksh(epmc).pdf DeepDyve Pubget Overpricing