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10.1136/bmjopen-2016-012212

http://scihub22266oqcxt.onion/10.1136/bmjopen-2016-012212
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C5372122!5372122!28336734
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suck abstract from ncbi


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pmid28336734      BMJ+Open 2017 ; 7 (3): ä
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  • Time to publication for publicly funded clinical trials in Australia: an observational study #MMPMID28336734
  • Strand LB; Clarke P; Graves N; Barnett AG
  • BMJ Open 2017[]; 7 (3): ä PMID28336734show ga
  • Objective: To examine the length of time between receiving funding and publishing the protocol and main paper for randomised controlled trials. Design: An observational study using survival analysis. Setting: Publicly funded health and medical research in Australia. Participants: Randomised controlled trials funded by the National Health and Medical Research Council of Australia between 2008 and 2010. Main outcome measures: Time from funding to the protocol paper and main results paper. Multiple variable survival models examining whether study characteristics predicted publication times. Results: We found 77 studies with a total funding of $A59 million. The median time to publication of the protocol paper was 6.4?years after funding (95% CI 4.1 to 8.1). The proportion with a published protocol paper 8?years after funding was 0.61 (95% CI 0.48 to 0.74). The median time to publication of the main results paper was 7.1?years after funding (95% CI 6.3 to 7.6). The proportion with a published main results paper 8?years after funding was 0.72 (95% CI 0.56 to 0.87). The HRs for how study characteristics might influence timing were generally close to one with narrow CIs, the notable exception was that a longer study length lengthened the time to the main paper (HR=0.62 per extra study year, 95% CI 0.43 to 0.89). Conclusions: Despite the widespread registration of clinical trials, there remain serious concerns of trial results not being published or being published with a long delay. We have found that these same concerns apply to protocol papers, which should be publishable soon after funding. Funding agencies could set a target of publishing the protocol paper within 18?months of funding.
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