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10.3390/cells6010008 http://scihub22266oqcxt.onion/10.3390/cells6010008 C5371873!5371873!28304334     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2017 ; 6 (1): ä Nephropedia Template TP {{tp|p=28304334|t=2017. KDM2 Family Members are Regulated by HIF-1 in Hypoxia |pdf=|usr=}}{{28304334}} gab.com Text KDM2 Family Members are Regulated by HIF-1 in Hypoxia JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=28304334 #FOAvip Hypoxia is not only a developmental cue but also a stress and pathological stimulus in many human diseases. The response to hypoxia at the cellular level relies on the activity of the transcription factor family, hypoxia inducible factor (HIF). HIF-1 is responsible for the acute response and transactivates a variety of genes involved in cellular metabolism, cell death, and cell growth. Here, we show that hypoxia results in increased mRNA levels for human lysine (K)-specific demethylase 2 (KDM2) family members, KDM2A and KDM2B, and also for Drosophila melanogaster KDM2, a histone and protein demethylase. In human cells, KDM2 family member?s mRNA levels are regulated by HIF-1 but not HIF-2 in hypoxia. Interestingly, only KDM2A protein levels are significantly induced in a HIF-1-dependent manner, while KDM2B protein changes in a cell type-dependent manner. Importantly, we demonstrate that in human cells, KDM2A regulation by hypoxia and HIF-1 occurs at the level of promoter, with HIF-1 binding to the KDM2A promoter being required for RNA polymerase II recruitment. Taken together, these results demonstrate that KDM2 is a novel HIF target that can help coordinate the cellular response to hypoxia. In addition, these results might explain why KDM2 levels are often deregulated in human cancers. Twit Text FOAVip KDM2 Family Members are Regulated by HIF-1 in Hypoxia ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=28304334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28304334 #FOAvip English Wikipedia <ref>{{Cite pmid|28304334}}</ref> KDM2 Family Members are Regulated by HIF-1 in Hypoxia #MMPMID28304334 Batie M; Druker J; D?Ignazio L; Rocha S Cells 2017[Mar]; 6 (1): ä PMID28304334show ga Hypoxia is not only a developmental cue but also a stress and pathological stimulus in many human diseases. The response to hypoxia at the cellular level relies on the activity of the transcription factor family, hypoxia inducible factor (HIF). HIF-1 is responsible for the acute response and transactivates a variety of genes involved in cellular metabolism, cell death, and cell growth. Here, we show that hypoxia results in increased mRNA levels for human lysine (K)-specific demethylase 2 (KDM2) family members, KDM2A and KDM2B, and also for Drosophila melanogaster KDM2, a histone and protein demethylase. In human cells, KDM2 family member?s mRNA levels are regulated by HIF-1 but not HIF-2 in hypoxia. Interestingly, only KDM2A protein levels are significantly induced in a HIF-1-dependent manner, while KDM2B protein changes in a cell type-dependent manner. Importantly, we demonstrate that in human cells, KDM2A regulation by hypoxia and HIF-1 occurs at the level of promoter, with HIF-1 binding to the KDM2A promoter being required for RNA polymerase II recruitment. Taken together, these results demonstrate that KDM2 is a novel HIF target that can help coordinate the cellular response to hypoxia. In addition, these results might explain why KDM2 levels are often deregulated in human cancers. äKDM2 Family Members are Regulated by HIF-1 in Hypoxia (epmc).pdf DeepDyve Pubget Overpricing