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10.3390/cells6010005 http://scihub22266oqcxt.onion/10.3390/cells6010005 C5371870!5371870!28178187     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2017 ; 6 (1): ä Nephropedia Template TP {{tp|p=28178187|t=2017. May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells |pdf=|usr=}}{{28178187}} gab.com Text May I Cut in Gene Editing Approaches in Human Induced Pluripotent Stem Cells JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=28178187 #FOAvip In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods. Twit Text FOAVip May I Cut in Gene Editing Approaches in Human Induced Pluripotent Stem Cells ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=28178187 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28178187 #FOAvip English Wikipedia <ref>{{Cite pmid|28178187}}</ref> May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells #MMPMID28178187 Brookhouser N; Raman S; Potts C; Brafman DA Cells 2017[Mar]; 6 (1): ä PMID28178187show ga In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods. äMay I Cut in? Gene Editing Approaches in Human Induced Pluripotent Ste(epmc).pdf DeepDyve Pubget Overpricing