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10.3390/toxins9030090 http://scihub22266oqcxt.onion/10.3390/toxins9030090 C5371845!5371845!28257106     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxins+(Basel) 2017 ; 9 (3): ä Nephropedia Template TP {{tp|p=28257106|t=2017. Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom |pdf=|usr=}}{{28257106}} gab.com Text Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28257106 #FOAvip Envenomation by Loxosceles spider can result in two clinical manifestations: cutaneous and systemic loxoscelism, the latter of which includes renal failure. Although incidence of renal failure is low, it is the main cause of death, occurring mainly in children. The sphingomyelinase D (SMase D) is the main component in Loxosceles spider venom responsible for local and systemic manifestations. This study aimed to investigate the toxicity of L. intermedia venom and SMase D on kidney cells, using both In vitro and in vivo models, and the possible involvement of endogenous metalloproteinases (MMP). Results demonstrated that venom and SMase D are able to cause death of human kidney cells by apoptosis, concomitant with activation and secretion of extracellular matrix metalloproteases, MMP-2 and MMP-9. Furthermore, cell death and MMP synthesis and secretion can be prevented by tetracycline. In a mouse model of systemic loxoscelism, Loxosceles venom-induced kidney failure was observed, which was abrogated by administration of tetracycline. These results indicate that MMPs may play an important role in Loxosceles venom-induced kidney injury and that tetracycline administration may be useful in the treatment of human systemic loxoscelism. Twit Text FOAVip Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28257106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28257106 #FOAvip English Wikipedia <ref>{{Cite pmid|28257106}}</ref> Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom #MMPMID28257106 Okamoto CK; van den Berg CW; Masashi M; Gonçalves-de-Andrade RM; Tambourgi DV Toxins (Basel) 2017[Mar]; 9 (3): ä PMID28257106show ga Envenomation by Loxosceles spider can result in two clinical manifestations: cutaneous and systemic loxoscelism, the latter of which includes renal failure. Although incidence of renal failure is low, it is the main cause of death, occurring mainly in children. The sphingomyelinase D (SMase D) is the main component in Loxosceles spider venom responsible for local and systemic manifestations. This study aimed to investigate the toxicity of L. intermedia venom and SMase D on kidney cells, using both In vitro and in vivo models, and the possible involvement of endogenous metalloproteinases (MMP). Results demonstrated that venom and SMase D are able to cause death of human kidney cells by apoptosis, concomitant with activation and secretion of extracellular matrix metalloproteases, MMP-2 and MMP-9. Furthermore, cell death and MMP synthesis and secretion can be prevented by tetracycline. In a mouse model of systemic loxoscelism, Loxosceles venom-induced kidney failure was observed, which was abrogated by administration of tetracycline. These results indicate that MMPs may play an important role in Loxosceles venom-induced kidney injury and that tetracycline administration may be useful in the treatment of human systemic loxoscelism. äTetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom (epmc).pdf DeepDyve Pubget Overpricing