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10.1021/acsami.6b07252 http://scihub22266oqcxt.onion/10.1021/acsami.6b07252 C5371828!5371828!27540627     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Appl+Mater+Interfaces 2016 ; 8 (36): 23509-16 Nephropedia Template TP {{tp|p=27540627|t=2016. PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity |pdf=|usr=}}{{27540627}} gab.com Text PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity JO: ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=27540627 #FOAvip Molecular imprinting, which involves the formation of artificial recognition elements or cavities with complementary shape and chemical functionality to the target species, is a powerful method to overcome a number of limitations associated with natural antibodies. An important but often overlooked consideration in the design of artificial biorecognition elements based on molecular imprinting is the nonspecific binding of interfering species to noncavity regions of the imprinted polymer. Here, we demonstrate a universal method, namely, PEGylation of the noncavity regions of the imprinted polymer, to minimize the nonspecific binding and significantly enhance the selectivity of the molecular imprinted polymer for the target biomolecules. The nonspecific binding, as quantified by the localized surface plasmon resonance shift of imprinted plasmonic nanorattles upon exposure to common interfering proteins, was found to be more than 10 times lower compared to the non-PEGylated counterparts. The method demonstrated here can be broadly applied to a wide variety of functional monomers employed for molecular imprinting. The significantly higher selectivity of PEGylated molecular imprints takes biosensors based on these artificial biorecognition elements closer to real-world applications. Twit Text FOAVip PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity ????ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=27540627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27540627 #FOAvip English Wikipedia <ref>{{Cite pmid|27540627}}</ref> PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity #MMPMID27540627 Luan J; Liu KK; Tadepalli S; Jiang Q; Morrissey JJ; Kharasch ED; Singamaneni S ACS Appl Mater Interfaces 2016[Sep]; 8 (36): 23509-16 PMID27540627show ga Molecular imprinting, which involves the formation of artificial recognition elements or cavities with complementary shape and chemical functionality to the target species, is a powerful method to overcome a number of limitations associated with natural antibodies. An important but often overlooked consideration in the design of artificial biorecognition elements based on molecular imprinting is the nonspecific binding of interfering species to noncavity regions of the imprinted polymer. Here, we demonstrate a universal method, namely, PEGylation of the noncavity regions of the imprinted polymer, to minimize the nonspecific binding and significantly enhance the selectivity of the molecular imprinted polymer for the target biomolecules. The nonspecific binding, as quantified by the localized surface plasmon resonance shift of imprinted plasmonic nanorattles upon exposure to common interfering proteins, was found to be more than 10 times lower compared to the non-PEGylated counterparts. The method demonstrated here can be broadly applied to a wide variety of functional monomers employed for molecular imprinting. The significantly higher selectivity of PEGylated molecular imprints takes biosensors based on these artificial biorecognition elements closer to real-world applications. äPEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Se(epmc).pdf DeepDyve Pubget Overpricing