Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28348067
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mol+Syst+Biol
2017 ; 13
(3
): 922
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Proteomics and integrative omic approaches for understanding host-pathogen
interactions and infectious diseases
#MMPMID28348067
Jean Beltran PM
; Federspiel JD
; Sheng X
; Cristea IM
Mol Syst Biol
2017[Mar]; 13
(3
): 922
PMID28348067
show ga
Organisms are constantly exposed to microbial pathogens in their environments.
When a pathogen meets its host, a series of intricate intracellular interactions
shape the outcome of the infection. The understanding of these host-pathogen
interactions is crucial for the development of treatments and preventive measures
against infectious diseases. Over the past decade, proteomic approaches have
become prime contributors to the discovery and understanding of host-pathogen
interactions that represent anti- and pro-pathogenic cellular responses. Here, we
review these proteomic methods and their application to studying viral and
bacterial intracellular pathogens. We examine approaches for defining spatial and
temporal host-pathogen protein interactions upon infection of a host cell.
Further expanding the understanding of proteome organization during an infection,
we discuss methods that characterize the regulation of host and pathogen
proteomes through alterations in protein abundance, localization, and
post-translational modifications. Finally, we highlight bioinformatic tools
available for analyzing such proteomic datasets, as well as novel strategies for
integrating proteomics with other omic tools, such as genomics, transcriptomics,
and metabolomics, to obtain a systems-level understanding of infectious diseases.