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2017 ; 5
(6
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide
on the kidney proteome in db/db mice
#MMPMID28330952
Liljedahl L
; Norlin J
; McGuire JN
; James P
Physiol Rep
2017[Mar]; 5
(6
): ä PMID28330952
show ga
Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world
population and type 2 DM accounts for 90% of those. A common consequence of DM is
kidney complications, which could lead to kidney failure. We studied the
potential effects of treatment with insulin and the glucagon-like peptide 1
receptor (GLP-1R) agonist liraglutide on the diabetic kidney proteome through the
use of the db/db mouse model system and mass spectrometry (MS). Multivariate
analyses revealed distinct effects of insulin and liraglutide on the db/db kidney
proteome, which was seen on the protein levels of, for example, pterin-4
?-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1?
(PCBD1), neural precursor cell expressed developmentally down-regulated-8
(NEDD8), transcription elongation factor-B polypeptide-1 (ELOC) and hepcidin
(HEPC). Furthermore, the separation of the insulin, liraglutide and vehicle db/db
mouse groups in multivariate analyses was not mainly related to the albumin
excretion rate (AER) or the level of glycated hemoglobin A(1c) (HbA(1c)%) in the
mice. In summary, we show that insulin and liraglutide give rise to separate
protein profiles in the db/db mouse kidney.
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