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2017 ; 96
(12
): e6376
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Clinical study on single-organ cutaneous small vessels vasculitis (SoCSVV)
#MMPMID28328827
Pastuszczak M
; Celi?ska-Löwenhoff M
; Su?owicz J
; Wojas-Pelc A
; Musia? J
Medicine (Baltimore)
2017[Mar]; 96
(12
): e6376
PMID28328827
show ga
Leukocytoclastic vasculitis (LCV) is a heterogenous group of disorders that may
manifest as a mild disease isolated to the skin or be a part of life-threatening
systemic vasculitis. According to the 2012 Chapel Hill Consensus Conference
nomenclature, patients presenting symptoms of LCV confined only to the skin
should be defined as suffering from a single-organ cutaneous small vessel
vasculitis (SoCSVV). SoCSVV is a benign disease with a good clinical outcome but
with a significant risk of relapse and skin ulcer formation.The aim of the
current study was to characterize SoCSVV and to identify factors that may be
associated with the risk of recurrence and skin ulcers.Medical records of
patients with LCV hospitalized at the Department of Dermatology at University
Hospital in Cracow in the years 2010 to 2015 were analyzed.A total of 24 patients
fulfilled criteria of SoCSVV. Drugs and preceding infections were identified as
precipitating factors in 40% and 20% of cases, respectively. Skin lesions other
than palpable purpura (i.e., macules, urticarial vasculitis, or ulcers) were
identified in almost half of the patients. Interestingly, the presence of macules
independently increased the risk of skin ulcer formation (odds ratio?=?16; 95%
confidence interval: 1.5-176.6; P?=?0.0075) in the multivariate logistic
regression analysis. One-quarter of patients with SoCSVV experienced relapse
during the 6-month follow-up. The greater number of affected skin areas was an
independent risk factor of recurrence (odds ratio?=?5; 95% confidence interval:
2-45; P?=?0.02).SoCSVV was usually associated with drugs and preceding
infections. The disease relapses in approximately one-quarter of the patients.
The more severe the skin involvement in the course of SoCSVV, the higher is the
risk of recurrence.
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