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10.1097/MD.0000000000006376

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C5371464!5371464!28328827
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suck abstract from ncbi


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pmid28328827      Medicine+(Baltimore) 2017 ; 96 (12): ä
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  • Clinical study on single-organ cutaneous small vessels vasculitis (SoCSVV) #MMPMID28328827
  • Pastuszczak M; Celi?ska-Löwenhoff M; Su?owicz J; Wojas-Pelc A; Musia? J
  • Medicine (Baltimore) 2017[Mar]; 96 (12): ä PMID28328827show ga
  • Leukocytoclastic vasculitis (LCV) is a heterogenous group of disorders that may manifest as a mild disease isolated to the skin or be a part of life-threatening systemic vasculitis. According to the 2012 Chapel Hill Consensus Conference nomenclature, patients presenting symptoms of LCV confined only to the skin should be defined as suffering from a single-organ cutaneous small vessel vasculitis (SoCSVV). SoCSVV is a benign disease with a good clinical outcome but with a significant risk of relapse and skin ulcer formation.The aim of the current study was to characterize SoCSVV and to identify factors that may be associated with the risk of recurrence and skin ulcers.Medical records of patients with LCV hospitalized at the Department of Dermatology at University Hospital in Cracow in the years 2010 to 2015 were analyzed.A total of 24 patients fulfilled criteria of SoCSVV. Drugs and preceding infections were identified as precipitating factors in 40% and 20% of cases, respectively. Skin lesions other than palpable purpura (i.e., macules, urticarial vasculitis, or ulcers) were identified in almost half of the patients. Interestingly, the presence of macules independently increased the risk of skin ulcer formation (odds ratio?=?16; 95% confidence interval: 1.5?176.6; P?=?0.0075) in the multivariate logistic regression analysis. One-quarter of patients with SoCSVV experienced relapse during the 6-month follow-up. The greater number of affected skin areas was an independent risk factor of recurrence (odds ratio?=?5; 95% confidence interval: 2?45; P?=?0.02).SoCSVV was usually associated with drugs and preceding infections. The disease relapses in approximately one-quarter of the patients. The more severe the skin involvement in the course of SoCSVV, the higher is the risk of recurrence.
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