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2017 ; 96
(12
): e6160
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Curative effect of neutral macroporous resin hemoperfusion on treating
hemodialysis patients with refractory uremic pruritus
#MMPMID28328802
Li WH
; Yin YM
; Chen H
; Wang XD
; Yun H
; Li H
; Luo J
; Wang JW
Medicine (Baltimore)
2017[Mar]; 96
(12
): e6160
PMID28328802
show ga
This study aims to investigate the efficacy and safety of neutral macroporous
resin hemoperfusion in treating maintenance hemodialysis (MHD) patients with
refractory uremic pruritus (RUP).Ninety patients were enrolled and were randomly
divided into 3 groups: control group, experiment 1 group, and experiment 2 group.
Clinical symptom scores of skin itching were recorded before and at 4 and 8 weeks
after the treatment. In addition, serum parathyroid hormone (PTH), calcium (Ca),
phosphorus (P), and C-reactive protein (CRP) were detected; and the
calcium-phosphorus product ([Ca]?×?[P]) was calculated to compare the curative
effect.VSA score, modified Duo pruritus score, and CRP: these indices decreased
to some extent at 4 and 8 weeks after treatment in the 2 experiment groups,
compared with pretreatment (P?0.05); and differences among these 3 groups were
statistically significant (P?0.05). PTH, P, and [Ca]?×?[P]: these indices
decreased to some extent at 4 and 8 weeks after treatment in the 2 experiment
groups, compared with pretreatment (P?0.05); and differences between the
control and experiment 1 groups, as well as between the control and experiment 2
groups, were statistically significant (P?0.05). However, the difference
between the experiment 1 and experiment 2 groups were not statistically
significant (P?0.05).The effects of HA330 and HA130 resin hemoperfusion
apparatus on secondary hyperparathyroidism and the disorder of calcium and
phosphorus metabolism are similar. The mechanism may be related to its strong
adsorption effect, and its capacity to widely remove inflammatory mediators,
immune mediators, and endotoxins.