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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Reprod+Immunol 2017 ; 77 (3): ä Nephropedia Template TP
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Neutrophil extracellular traps in acute chorioamnionitis: a mechanism of host defense #MMPMID28045214
Gomez-Lopez N; Romero R; Leng Y; Garcia-Flores V; Xu Y; Miller D; Hassan SS
Am J Reprod Immunol 2017[Mar]; 77 (3): ä PMID28045214show ga
Problem: Neutrophil extracellular traps (NETs) were recently described as a mechanism for microbial killing in the amniotic cavity of women with intra-amniotic infection. Such a clinical condition can result in acute chorioamnionitis, a placental lesion characterized by the infiltration of maternal neutrophils in the chorioamniotic membranes. Herein, we investigated whether these infiltrating neutrophils form NETs in the chorioamniotic membranes from women who underwent spontaneous term or preterm labor with acute chorioamnionitis. Method of Study: Chorioamniotic membrane samples were collected from women who underwent spontaneous term or preterm labor with acute chorioamnionitis (n=10 each). Controls included chorioamniotic membrane samples from women who delivered at term or preterm with or without labor, in the absence of acute chorioamnionitis (n=10 each). NETs were visualized and semi-quantified in the chorioamniotic membranes by using antibodies against neutrophil elastase and histone H3, in combination with DAPI staining. Results: NETs were abundant in the chorioamniotic membranes from women who underwent spontaneous term or preterm labor with acute chorioamnionitis. NETs were rarely found, or not visualized at all, in the chorioamniotic membranes from women who delivered at term or preterm with or without labor, in the absence of acute chorioamnionitis. Conclusion: NETs are abundant in the chorioamniotic membranes from women who underwent spontaneous term or preterm labor with acute chorioamnionitis. These findings suggest that chorioamniotic neutrophils can form NETs as a mechanism of host defense against infection or danger signals.