Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28367242
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
The NOR1/OSCP1 proteins in cancer: from epigenetic silencing to functional
characterization of a novel tumor suppressor
#MMPMID28367242
Yi M
; Yang J
; Li W
; Li X
; Xiong W
; McCarthy JB
; Li G
; Xiang B
J Cancer
2017[]; 8
(4
): 626-635
PMID28367242
show ga
NOR1 (Oxidored-nitro domain-containing protein 1), also known as OSCP1, was first
identified in nasopharyngeal carcinoma (NPC) cells in 2003. NOR1 is
evolutionarily conserved among species with its expression is restricted to
brain, testis and respiratory epithelial cells. NOR1 was downregulated in NPC and
the downregulation associates with poor prognosis. Previous study demonstrated
that hypermethylation of NOR1 promoter was observed in NPC and hematological
malignancies, which has been believed to be the main epigenetic cause for NOR1
silencing in these cancers. Recently, the NOR1 tumor suppressor status has been
fully established. NOR1 inhibited cancer cell growth by disturbing tumor cell
energe metabolism. NOR1 also promote tumor cells apoptosis in oxidative stress
and hypoxia by inhibition of stress induced autophagy. Moreover, NOR1 suppressed
cancer cell epithelial-mesenchymal transition, invasion and metastasis via
activation of FOXA1/HDAC2-slug regulatory network. Deciphering the molecular
mechanisms underlying NOR1 mediated tumor suppressive role would be helpful to a
deeper understanding of carcinogenesis and, furthermore, to the development of
new therapeutic approaches. Here we summarize the current knowledge on NOR1
focusing on its expression pattern, epigenetic and genetic association with human
cancers and its biological functions. This review will also elucidate the
potential application of NOR1/OSCP1 for some human malignancies.
free
free
free
