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10.7150/ijbs.16635 http://scihub22266oqcxt.onion/10.7150/ijbs.16635 C5370442!5370442 !28367099     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28367099 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Biol+Sci 2017 ; 13 (3 ): 349-357 Nephropedia Template TP {{tp|p=28367099 |t=2017. Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c |pdf=|usr=}}{{28367099 }} gab.com Text Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c JO: Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28367099 #FOAvip Sterol regulatory element binding proteins (SREBPs) are master regulators of hepatic lipid homeostasis. Aberrant expression of SREBPs frequently leads to lipid metabolism dysregulation. Long non-coding RNAs (lncRNAs) have been identified with diverse biological functions, but the effects of lncRNAs on lipid metabolism are rarely reported. Here, we identified a novel human specific lncRNA, lncHR1, as a negative regulator of SREBP-1c expression. Overexpression of lncHR1 inhibited expression of SREBP-1c and fatty acid synthase (FAS) and then repressed oleic acid-induced hepatic cell triglyceride (TG) and lipid droplet (LD) accumulation. In vivo, the data of established transgenic animals showed that mice with lncHR1 expression had less hepatic expression of SREBP-1c, FAS, Acetyl-CoA carboxylase ? (ACC?), and less hepatic and plasma TG after being fed a high-fat diet. Therefore, we report a novel lncRNA which can decrease lipid metabolism by repressing SREBP-1c gene expression. Twit Text FOAVip Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c ????Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28367099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28367099 #FOAvip English Wikipedia <ref>{{Cite pmid|28367099 }}</ref> Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c #MMPMID28367099 Li D ; Cheng M ; Niu Y ; Chi X ; Liu X ; Fan J ; Fan H ; Chang Y ; Yang W Int J Biol Sci 2017[]; 13 (3 ): 349-357 PMID28367099 show ga Sterol regulatory element binding proteins (SREBPs) are master regulators of hepatic lipid homeostasis. Aberrant expression of SREBPs frequently leads to lipid metabolism dysregulation. Long non-coding RNAs (lncRNAs) have been identified with diverse biological functions, but the effects of lncRNAs on lipid metabolism are rarely reported. Here, we identified a novel human specific lncRNA, lncHR1, as a negative regulator of SREBP-1c expression. Overexpression of lncHR1 inhibited expression of SREBP-1c and fatty acid synthase (FAS) and then repressed oleic acid-induced hepatic cell triglyceride (TG) and lipid droplet (LD) accumulation. In vivo, the data of established transgenic animals showed that mice with lncHR1 expression had less hepatic expression of SREBP-1c, FAS, Acetyl-CoA carboxylase ? (ACC?), and less hepatic and plasma TG after being fed a high-fat diet. Therefore, we report a novel lncRNA which can decrease lipid metabolism by repressing SREBP-1c gene expression. |Animals [MESH] |Blotting, Western [MESH] |Cell Line, Tumor [MESH] |Hepacivirus/pathogenicity [MESH] |Humans [MESH] |In Situ Hybridization, Fluorescence [MESH] |Lipid Metabolism/genetics/physiology [MESH] |Liver/*metabolism/pathology/virology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |RNA, Long Noncoding/genetics/*metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Sterol Regulatory Element Binding Protein 1/genetics/*metabolism [MESH]Identification of a novel human long non-coding RNA that regulates hep(epmc).pdf DeepDyve Pubget Overpricing