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10.4103/jpp.JPP_153_16 http://scihub22266oqcxt.onion/10.4103/jpp.JPP_153_16 C5370323!5370323!28405131     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pharmacol+Pharmacother 2017 ; 8 (1): 14-20 Nephropedia Template TP {{tp|p=28405131|t=2017. Indocyanine Green-001 (ICG-001) Attenuates Wnt/?-catenin-induces Myocardial Injury Following Sepsis |pdf=|usr=}}{{28405131}} gab.com Text Indocyanine Green-001 (ICG-001) Attenuates Wnt/ -catenin-induces Myocardial Injury Following Sepsis JO: J Pharmacol Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=28405131 #FOAvip Objective:: To investigate the mechanistic pathway of both indocyanine green (ICG)-001 in attenuated endotoxemia-induced cardiac depression through downregulation cardiac Wnt/ ?-catenin cell signaling. Materials and Methods:: Adult (4?6 months) male Albino-Webster mice, their weights ranged from 25 to 30 g, were pretreated with ICG-001 i.p., following cecal ligation and puncture (CLP). Left ventricle (LV) function was assessed using a microcatheter system. Monocyte chemoattractant protein-1 (MCP-1) and cytokines mediators in plasma and myocardium were analyzed by enzyme-linked immunosorbent assay. Further, the cardiac Wnt protein measured by quantitative real-time polymerase chain reaction while ?-catenin analysis through Western blotting procedure. The pathological changes and cells injury in the myocardium were examined using hematoxylin and eosin staining. Results:: CLP mice displayed worse LV function. The exaggerated cardiac depression in CLP mice was associated with higher levels of MCP-1 and cytokines in plasma and myocardium together with greater cardiac levels of cardiac troponin-I and Wnt/?-catenin. Neutralization of sepsis by either ICG-001resulted in improved LV function and reductions in inflammatory mediators. Conclusion:: Taken together, these data showed that ICG-001 improved LV function following sepsis through downregulation of Wnt/?-catenin and serve as a potential mechanistic pathway ICG-001 in therapeutic cardiac endotoxemia in animal model. Twit Text FOAVip Indocyanine Green-001 (ICG-001) Attenuates Wnt/ -catenin-induces Myocardial Injury Following Sepsis ????J Pharmacol Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=28405131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405131 #FOAvip English Wikipedia <ref>{{Cite pmid|28405131}}</ref> Indocyanine Green-001 (ICG-001) Attenuates Wnt/?-catenin-induces Myocardial Injury Following Sepsis #MMPMID28405131 Yousif NG; Hadi NR; Hassan AM J Pharmacol Pharmacother 2017[Jan]; 8 (1): 14-20 PMID28405131show ga Objective:: To investigate the mechanistic pathway of both indocyanine green (ICG)-001 in attenuated endotoxemia-induced cardiac depression through downregulation cardiac Wnt/ ?-catenin cell signaling. Materials and Methods:: Adult (4?6 months) male Albino-Webster mice, their weights ranged from 25 to 30 g, were pretreated with ICG-001 i.p., following cecal ligation and puncture (CLP). Left ventricle (LV) function was assessed using a microcatheter system. Monocyte chemoattractant protein-1 (MCP-1) and cytokines mediators in plasma and myocardium were analyzed by enzyme-linked immunosorbent assay. Further, the cardiac Wnt protein measured by quantitative real-time polymerase chain reaction while ?-catenin analysis through Western blotting procedure. The pathological changes and cells injury in the myocardium were examined using hematoxylin and eosin staining. Results:: CLP mice displayed worse LV function. The exaggerated cardiac depression in CLP mice was associated with higher levels of MCP-1 and cytokines in plasma and myocardium together with greater cardiac levels of cardiac troponin-I and Wnt/?-catenin. Neutralization of sepsis by either ICG-001resulted in improved LV function and reductions in inflammatory mediators. Conclusion:: Taken together, these data showed that ICG-001 improved LV function following sepsis through downregulation of Wnt/?-catenin and serve as a potential mechanistic pathway ICG-001 in therapeutic cardiac endotoxemia in animal model. äIndocyanine Green-001 (ICG-001) Attenuates Wnt/?-catenin-induces Myoca(epmc).pdf DeepDyve Pubget Overpricing