Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fimmu.2017.00370 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00370 C5370275!5370275!28405194     free     free     free       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28405194|t=2017. Modeling Natural Killer Cell Targeted Immunotherapies |pdf=|usr=}}{{28405194}} gab.com Text Modeling Natural Killer Cell Targeted Immunotherapies JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28405194 #FOAvip Animal models have extensively contributed to our understanding of human immunobiology and to uncover the underlying pathological mechanisms occurring in the development of diseases. However, mouse models do not reproduce the genetic and molecular complexity inherent in human disease conditions. Human immune system (HIS) mouse models that are susceptible to human pathogens and can recapitulate human hematopoiesis and tumor immunobiology provide one means to bridge the interspecies gap. Natural killer cells are the founding member of the innate lymphoid cell family. They exert a rapid and strong immune response against tumor and pathogen-infected cells. Their antitumor features have long been exploited for therapeutic purposes in the context of cancer. In this review, we detail the development of highly immunodeficient mouse strains and the models currently used in cancer research. We summarize the latest improvements in adoptive natural killer (NK) cell therapies and the development of novel NK cell sources. Finally, we discuss the advantages of HIS mice to study the interactions between human NK cells and human cancers and to develop new therapeutic strategies. Twit Text FOAVip Modeling Natural Killer Cell Targeted Immunotherapies ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28405194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405194 #FOAvip English Wikipedia <ref>{{Cite pmid|28405194}}</ref> Modeling Natural Killer Cell Targeted Immunotherapies #MMPMID28405194 Lopez-Lastra S; Di Santo JP Front Immunol 2017[]; 8 (ä): ä PMID28405194show ga Animal models have extensively contributed to our understanding of human immunobiology and to uncover the underlying pathological mechanisms occurring in the development of diseases. However, mouse models do not reproduce the genetic and molecular complexity inherent in human disease conditions. Human immune system (HIS) mouse models that are susceptible to human pathogens and can recapitulate human hematopoiesis and tumor immunobiology provide one means to bridge the interspecies gap. Natural killer cells are the founding member of the innate lymphoid cell family. They exert a rapid and strong immune response against tumor and pathogen-infected cells. Their antitumor features have long been exploited for therapeutic purposes in the context of cancer. In this review, we detail the development of highly immunodeficient mouse strains and the models currently used in cancer research. We summarize the latest improvements in adoptive natural killer (NK) cell therapies and the development of novel NK cell sources. Finally, we discuss the advantages of HIS mice to study the interactions between human NK cells and human cancers and to develop new therapeutic strategies. äModeling Natural Killer Cell Targeted Immunotherapies (epmc).pdf DeepDyve Pubget Overpricing