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10.3389/fonc.2017.00058 http://scihub22266oqcxt.onion/10.3389/fonc.2017.00058 C5370238!5370238!28405578     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Oncol 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28405578|t=2017. The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells |pdf=|usr=}}{{28405578}} gab.com Text The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28405578 #FOAvip Mitochondria can receive, integrate, and transmit a variety of signals to shape many biochemical activities of the cell. In the process of tumor onset and growth, mitochondria contribute to the capability of cells of escaping death insults, handling changes in ROS levels, rewiring metabolism, and reprograming gene expression. Therefore, mitochondria can tune the bioenergetic and anabolic needs of neoplastic cells in a rapid and flexible way, and these adaptations are required for cell survival and proliferation in the fluctuating environment of a rapidly growing tumor mass. The molecular bases of pro-neoplastic mitochondrial adaptations are complex and only partially understood. Recently, the mitochondrial molecular chaperone TRAP1 (tumor necrosis factor receptor associated protein 1) was identified as a key regulator of mitochondrial bioenergetics in tumor cells, with a profound impact on neoplastic growth. In this review, we analyze these findings and discuss the possibility that targeting TRAP1 constitutes a new antitumor approach. Twit Text FOAVip The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28405578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405578 #FOAvip English Wikipedia <ref>{{Cite pmid|28405578}}</ref> The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells #MMPMID28405578 Masgras I; Sanchez-Martin C; Colombo G; Rasola A Front Oncol 2017[]; 7 (ä): ä PMID28405578show ga Mitochondria can receive, integrate, and transmit a variety of signals to shape many biochemical activities of the cell. In the process of tumor onset and growth, mitochondria contribute to the capability of cells of escaping death insults, handling changes in ROS levels, rewiring metabolism, and reprograming gene expression. Therefore, mitochondria can tune the bioenergetic and anabolic needs of neoplastic cells in a rapid and flexible way, and these adaptations are required for cell survival and proliferation in the fluctuating environment of a rapidly growing tumor mass. The molecular bases of pro-neoplastic mitochondrial adaptations are complex and only partially understood. Recently, the mitochondrial molecular chaperone TRAP1 (tumor necrosis factor receptor associated protein 1) was identified as a key regulator of mitochondrial bioenergetics in tumor cells, with a profound impact on neoplastic growth. In this review, we analyze these findings and discuss the possibility that targeting TRAP1 constitutes a new antitumor approach. äThe Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in(epmc).pdf DeepDyve Pubget Overpricing