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10.4049/jimmunol.1601135 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601135 C5370073!5370073!27591335     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 197 (6): 2045-50 Nephropedia Template TP {{tp|p=27591335|t=2016. Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway |pdf=|usr=}}{{27591335}} gab.com Text Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27591335 #FOAvip T cell activation is a complex process that requires multiple cell signaling pathways, including a primary recognition signal and additional costimulatory signals. TCR signaling in the absence of costimulatory signals can lead to an abortive attempt at activation and subsequent anergy. One of the best-characterized costimulatory pathways includes the Ig superfamily members CD28 and CTLA-4 and their ligands CD80 and CD86. The development of the fusion protein CTLA-4?Ig as an experimental and subsequent therapeutic tool is one of the major success stories in modern immunology. Abatacept and belatacept are clinically approved agents for the treatment of rheumatoid arthritis and renal transplantation, respectively. Future interventions may include selective CD28 blockade to block the costimulatory potential of CD28 while exploiting the coinhibitory effects of CTLA-4. Twit Text FOAVip Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27591335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27591335 #FOAvip English Wikipedia <ref>{{Cite pmid|27591335}}</ref> Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway #MMPMID27591335 Adams AB; Ford ML; Larsen CP J Immunol 2016[Sep]; 197 (6): 2045-50 PMID27591335show ga T cell activation is a complex process that requires multiple cell signaling pathways, including a primary recognition signal and additional costimulatory signals. TCR signaling in the absence of costimulatory signals can lead to an abortive attempt at activation and subsequent anergy. One of the best-characterized costimulatory pathways includes the Ig superfamily members CD28 and CTLA-4 and their ligands CD80 and CD86. The development of the fusion protein CTLA-4?Ig as an experimental and subsequent therapeutic tool is one of the major success stories in modern immunology. Abatacept and belatacept are clinically approved agents for the treatment of rheumatoid arthritis and renal transplantation, respectively. Future interventions may include selective CD28 blockade to block the costimulatory potential of CD28 while exploiting the coinhibitory effects of CTLA-4. äCostimulation Blockade in Autoimmunity and Transplantation: The CD28 P(epmc).pdf DeepDyve Pubget Overpricing