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10.18632/oncotarget.15216 http://scihub22266oqcxt.onion/10.18632/oncotarget.15216 C5370015!5370015 !28199981     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28199981 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (10 ): 16972-16987 Nephropedia Template TP {{tp|p=28199981 |t=2017. Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3?/?-catenin signaling |pdf=|usr=}}{{28199981 }} gab.com Text Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3 / -catenin signaling JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28199981 #FOAvip Cancer stem cells in liver cancer are thought to be responsible for tumor recurrence and metastasis. However, the factors that mediate this mechanism have yet to be completely elucidated. In this study, we isolated CD13+CD44+ sphere cells (SCs) derived from liver cancer tissues and SK-Hep-1 cells, which possessed cancer stem cell-like properties. Through cytokine array analysis, growth differentiation factor 15 (GDF15) was significantly increased in SCs. Clinical data showed GDF15 was overexpressed in liver cancer tissues and was positively related to pathological grading. GDF15 knockdown significantly inhibited the growth and metastasis of SCs through AKT/GSK-3?/?-catenin pathway suppression. Moreover, a PI3K inhibitor LY294002 inhibited AKT/GSK-3?/?-catenin pathway activated by GDF15 and attenuated GDF15-induced proliferation, colony formation and invasion of SCs. CONCLUSION: Our studies suggest that CD13+CD44+ SCs may represent a subset of LCSCs. GDF15 promotes the growth and metastasis of SCs by activating AKT/GSK-3?/?-catenin signaling pathway. Promisingly, GDF15 could be considered as a potential therapeutic target in liver cancer. Twit Text FOAVip Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3 / -catenin signaling ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28199981 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28199981 #FOAvip English Wikipedia <ref>{{Cite pmid|28199981 }}</ref> Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3?/?-catenin signaling #MMPMID28199981 Xu Q ; Xu HX ; Li JP ; Wang S ; Fu Z ; Jia J ; Wang L ; Zhu ZF ; Lu R ; Yao Z Oncotarget 2017[Mar]; 8 (10 ): 16972-16987 PMID28199981 show ga Cancer stem cells in liver cancer are thought to be responsible for tumor recurrence and metastasis. However, the factors that mediate this mechanism have yet to be completely elucidated. In this study, we isolated CD13+CD44+ sphere cells (SCs) derived from liver cancer tissues and SK-Hep-1 cells, which possessed cancer stem cell-like properties. Through cytokine array analysis, growth differentiation factor 15 (GDF15) was significantly increased in SCs. Clinical data showed GDF15 was overexpressed in liver cancer tissues and was positively related to pathological grading. GDF15 knockdown significantly inhibited the growth and metastasis of SCs through AKT/GSK-3?/?-catenin pathway suppression. Moreover, a PI3K inhibitor LY294002 inhibited AKT/GSK-3?/?-catenin pathway activated by GDF15 and attenuated GDF15-induced proliferation, colony formation and invasion of SCs. CONCLUSION: Our studies suggest that CD13+CD44+ SCs may represent a subset of LCSCs. GDF15 promotes the growth and metastasis of SCs by activating AKT/GSK-3?/?-catenin signaling pathway. Promisingly, GDF15 could be considered as a potential therapeutic target in liver cancer. |Animals [MESH] |Blotting, Western [MESH] |Carcinoma, Hepatocellular/genetics/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Chromones/pharmacology [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Female [MESH] |Glycogen Synthase Kinase 3 beta/*metabolism [MESH] |Growth Differentiation Factor 15/genetics/*metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Liver Neoplasms/genetics/*metabolism/pathology [MESH] |Male [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Middle Aged [MESH] |Morpholines/pharmacology [MESH] |Neoplasm Metastasis [MESH] |Neoplastic Stem Cells/*metabolism/pathology [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH] |RNA Interference [MESH] |Signal Transduction/drug effects [MESH] |Spheroids, Cellular/metabolism/pathology [MESH] |Transplantation, Heterologous [MESH]Growth differentiation factor 15 induces growth and metastasis of huma(epmc).pdf DeepDyve Pubget Overpricing