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10.18632/oncotarget.15181 http://scihub22266oqcxt.onion/10.18632/oncotarget.15181 C5369962!5369962!28187445     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (10): 16275-92 Nephropedia Template TP {{tp|p=28187445|t=2017. In vivo histone H1 migration from necrotic to viable tissue |pdf=|usr=}}{{28187445}} gab.com Text In vivo histone H1 migration from necrotic to viable tissue JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28187445 #FOAvip Necrosis is induced by ischemic conditions within the core of many solid tumors. Using fluorescent fusion proteins, we provide in vivo evidence of histone trafficking among cancer cells in implanted tumors. In particular, the most abundant H1 isoform (H1.2) was found to be transported from necrotic tumor cells into surrounding viable cells where histones are selectively taken up by energy-dependent endocytosis. We propose that intercellular histone trafficking could function as a target for drug delivery. This concept was validated using an anti-histone antibody that was co-internalized with histones from dead cells into viable ones surrounding the necrotic regions of a tumor, where some of the most chemoresistant cells reside. These findings demonstrate that cellular translocation of conjugated drugs using anti-histone antibodies is a promising strategy for targeted drug delivery to chemoresistant tumors. Twit Text FOAVip In vivo histone H1 migration from necrotic to viable tissue ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28187445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28187445 #FOAvip English Wikipedia <ref>{{Cite pmid|28187445}}</ref> In vivo histone H1 migration from necrotic to viable tissue #MMPMID28187445 Luhrs KA; Pink D; Schulte W; Zijlstra A; Lewis JD; Parseghian MH Oncotarget 2017[Mar]; 8 (10): 16275-92 PMID28187445show ga Necrosis is induced by ischemic conditions within the core of many solid tumors. Using fluorescent fusion proteins, we provide in vivo evidence of histone trafficking among cancer cells in implanted tumors. In particular, the most abundant H1 isoform (H1.2) was found to be transported from necrotic tumor cells into surrounding viable cells where histones are selectively taken up by energy-dependent endocytosis. We propose that intercellular histone trafficking could function as a target for drug delivery. This concept was validated using an anti-histone antibody that was co-internalized with histones from dead cells into viable ones surrounding the necrotic regions of a tumor, where some of the most chemoresistant cells reside. These findings demonstrate that cellular translocation of conjugated drugs using anti-histone antibodies is a promising strategy for targeted drug delivery to chemoresistant tumors. äIn vivo histone H1 migration from necrotic to viable tissue (epmc).pdf DeepDyve Pubget Overpricing