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2017 ; 96
(11
): e6352
Nephropedia Template TP
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Oral magnesium supplementation improves glycemic control and lipid profile in
children with type 1 diabetes and hypomagnesaemia
#MMPMID28296769
Shahbah D
; Hassan T
; Morsy S
; Saadany HE
; Fathy M
; Al-Ghobashy A
; Elsamad N
; Emam A
; Elhewala A
; Ibrahim B
; Gebaly SE
; Sayed HE
; Ahmed H
Medicine (Baltimore)
2017[Mar]; 96
(11
): e6352
PMID28296769
show ga
Dietary supplementation with magnesium (Mg) in addition to classical therapies
for diabetes may help in prevention or delaying of diabetic complications.We
aimed to evaluate the status of serum Mg in children with type 1 diabetes and
assessing its relationship to glycemic control and lipid profile. Then evaluating
the effect of oral Mg supplementation on glycemic control and lipid parameters.We
included 71 children at Pediatric Endocrinology Outpatient Clinic, Zagazig
University, Egypt with type 1 diabetes and assessed HBA1c, lipid profile, and
serum Mg at the start of study. Patients with serum Mg level?1.7?mg/dL were
given 300?mg Mg oxide for 3 months. After that we reevaluated HBA1c, lipid
profile, and serum Mg in all patients.The study included 71 patients with type 1
diabetes (32 males and 39 females); their mean age was 9.68?±?3.99 years. The
mean serum Mg level was 1.83?±?.27?mg/dL. Hypomagnesemia was detected in 28.2%
study patients. Serum Mg was found to be positively correlated with high density
lipoprotein, mean corpuscular volume and platelet count (P?0.001), and
negatively correlated with age, HbA1c, triglycerides, total cholesterol, low
density lipoprotein, and duration of diabetes (P?0.001). There was significant
reduction in HBA1c in group given Mg supplementation. HBA1c was initially
10.11%?±?0.87%. After 3 months of oral Mg supplementation it is reduced to
7.88%?±?0.42% (P?0.001). There was statistically significant difference in
lipid parameters in hypomagnesemic diabetic patients before and after Mg
supplementation with significant reduction in serum triglycerides, LDL, and total
cholesterol following Mg supplementation with P?0.001. Although HDL shows a
significant increase after Mg supplementation in hypomagnesemic diabetic children
with P?0.001.Correction of hypomagnesemia in type 1 diabetic children with oral
Mg supplements is associated with optimization of glycemic control and reduction
of atherogenic lipid fraction as well as increase in protective lipid fraction.