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2017 ; 96
(11
): e6312
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Pseudohypoparathyroidism with basal ganglia calcification: A case report of rare
cause of reversible parkinsonism
#MMPMID28296742
Song CY
; Zhao ZX
; Li W
; Sun CC
; Liu YM
Medicine (Baltimore)
2017[Mar]; 96
(11
): e6312
PMID28296742
show ga
RATIONALE: Parkinsonism can be secondary to many internal diseases, in some
certain conditions, it seems that the clinical manifestations of parkinsonism
presenting reversible. We report a case of patient with parkinsonism secondary to
pseudohypoparathyroidism, who improved markedly after the supplement of serum
calcium. PATIENT CONCERNS AND DIAGNOSES: A 52-year-old woman with acute
parkinsonism was diagnosed as pseudohypoparathyroidism after the conducting of
brain computed tomography, laboratory examinations, and gene detection. The son
of the patient was also examined and was diagnosed as pseudohypoparathyroidism,
who had ever complained of the history of epilepsy. The clinical manifestations
of parkinsonism of the patient was reevaluated after the supplement of serum
calcium according to the diagnosis. INTERVENTIONS AND OUTCOMES: The brain
computed tomography revealed the basal ganglia calcification of the patient,
accompanying by serum hypocalcemia and hyperphosphatemia. Loss of function
mutation also confirmed the diagnosis. Five days after the therapy targeting at
correction of serum hypocalcemia, the patient improved greatly in dyskinesia.
LESSONS: This study reported a patient presenting as acute reversible
parkinsonism, who was finally diagnosed as pseudohypoparathyroidism. It indicated
us that secondary parkinsonism should be carefully differentiated for its
dramatic treatment effect. And the family history of seizures might be an
indicator for the consideration of pseudohypoparathyroidism.