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10.1016/j.celrep.2017.02.013 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.02.013 C5369772!5369772 !28249168     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28249168 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2017 ; 18 (9 ): 2243-2255 Nephropedia Template TP {{tp|p=28249168 |t=2017. Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers |pdf=|usr=}}{{28249168 }} gab.com Text Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28249168 #FOAvip Mutant KRAS and c-MYC are oncogenic drivers and rational therapeutic targets for the treatment of pancreatic cancer. Although tumor growth and homeostasis are largely dependent on these oncogenes, a few residual cancer cells are able to survive the ablation of mutant KRAS and c-MYC. By performing a genome-wide gene expression analysis of in vivo-derived bulk tumor cells and residual cancer cells lacking the expression of mutant KRAS or c-MYC, we have identified an increase in autocrine IGF1/AKT signaling as a common survival mechanism in dormant cancer cells. The pharmacological inhibition of IGF-1R reduces residual disease burden and cancer recurrence, suggesting that this molecular pathway is crucial for the survival of cancer cells in the absence of the primary oncogenic drivers. Twit Text FOAVip Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28249168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28249168 #FOAvip English Wikipedia <ref>{{Cite pmid|28249168 }}</ref> Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers #MMPMID28249168 Rajbhandari N ; Lin WC ; Wehde BL ; Triplett AA ; Wagner KU Cell Rep 2017[Feb]; 18 (9 ): 2243-2255 PMID28249168 show ga Mutant KRAS and c-MYC are oncogenic drivers and rational therapeutic targets for the treatment of pancreatic cancer. Although tumor growth and homeostasis are largely dependent on these oncogenes, a few residual cancer cells are able to survive the ablation of mutant KRAS and c-MYC. By performing a genome-wide gene expression analysis of in vivo-derived bulk tumor cells and residual cancer cells lacking the expression of mutant KRAS or c-MYC, we have identified an increase in autocrine IGF1/AKT signaling as a common survival mechanism in dormant cancer cells. The pharmacological inhibition of IGF-1R reduces residual disease burden and cancer recurrence, suggesting that this molecular pathway is crucial for the survival of cancer cells in the absence of the primary oncogenic drivers. |Animals [MESH] |Autocrine Communication/*genetics [MESH] |Carcinogenesis/genetics/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |Gene Expression/genetics [MESH] |Genes, myc/genetics [MESH] |Humans [MESH] |Insulin-Like Growth Factor I/*genetics [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Mutation/genetics [MESH] |Neoplasm Recurrence, Local/genetics/pathology [MESH] |Oncogenes/*genetics [MESH] |Pancreas/pathology [MESH] |Pancreatic Neoplasms/*genetics/*pathology [MESH] |Proto-Oncogene Proteins c-akt/genetics [MESH] |Proto-Oncogene Proteins p21(ras)/genetics [MESH] |Receptor, IGF Type 1/genetics [MESH]Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in th(epmc).pdf DeepDyve Pubget Overpricing