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10.21873/cgp.20022

http://scihub22266oqcxt.onion/10.21873/cgp.20022
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C5369314!5369314!28387649
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suck abstract from ncbi


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pmid28387649      Cancer+Genomics+Proteomics 2017 ; 14 (2): 93-102
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  • Monochromosomal Hybrids and Chromosome Transfer: A Functional Approach for Gene Identification #MMPMID28387649
  • KANDPAL RP; SANDHU AK; KAUR G; KAUR GP; ATHWAL RS
  • Cancer Genomics Proteomics 2017[Mar]; 14 (2): 93-102 PMID28387649show ga
  • Functional complementation of cellular defects has been a valuable approach for localizing causative genes to specific chromosomes. The complementation strategy was followed by positional cloning and characterization of genes for their biological relevance. We herein describe strategies used for the construction of monochromosomal hybrids and their applications for cloning and characterization of genes related to cell growth, cell senescence and DNA repair. We have cloned RNaseT2, GluR6 (glutamate ionotropic receptor kainate type subunit 2-GRIK2) and protein tyrosine phosphatase, receptor type K (PTPRK) genes using these strategies.
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