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10.3390/ijerph14030301 http://scihub22266oqcxt.onion/10.3390/ijerph14030301 C5369137!5369137!28335443     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Environ+Res+Public+Health 2017 ; 14 (3): ä Nephropedia Template TP {{tp|p=28335443|t=2017. Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives |pdf=|usr=}}{{28335443}} gab.com Text Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives JO: Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=28335443 #FOAvip Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in patients with acute coronary syndrome (ACS) and in those undergoing percutaneous coronary intervention (PCI). However, recurrence events still remain, which may be partly due to inadequate platelet inhibition by standard clopidogrel therapy. Genetic polymorphisms involved in clopidogrel?s absorption, metabolism, and the P2Y12 receptor may interfere with its antiplatelet activity. Recent evidence indicated that epigenetic modification may also affect clopidogrel response. In addition, non-genetic factors such as demographics, disease complications, and drug-drug interactions can impair the antiplatelet effect of clopidogrel. The identification of factors contributing to the variation in clopidogrel response is needed to improve platelet inhibition and to reduce risk for cardiovascular events. This review encompasses the most recent updates on factors influencing pharmacokinetic and pharmacodynamic responses to clopidogrel. Twit Text FOAVip Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives ????Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=28335443 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28335443 #FOAvip English Wikipedia <ref>{{Cite pmid|28335443}}</ref> Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives #MMPMID28335443 Zhang YJ; Li MP; Tang J; Chen XP Int J Environ Res Public Health 2017[Mar]; 14 (3): ä PMID28335443show ga Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in patients with acute coronary syndrome (ACS) and in those undergoing percutaneous coronary intervention (PCI). However, recurrence events still remain, which may be partly due to inadequate platelet inhibition by standard clopidogrel therapy. Genetic polymorphisms involved in clopidogrel?s absorption, metabolism, and the P2Y12 receptor may interfere with its antiplatelet activity. Recent evidence indicated that epigenetic modification may also affect clopidogrel response. In addition, non-genetic factors such as demographics, disease complications, and drug-drug interactions can impair the antiplatelet effect of clopidogrel. The identification of factors contributing to the variation in clopidogrel response is needed to improve platelet inhibition and to reduce risk for cardiovascular events. This review encompasses the most recent updates on factors influencing pharmacokinetic and pharmacodynamic responses to clopidogrel. äPharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidence(epmc).pdf DeepDyve Pubget Overpricing