Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28357123
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Pharmacol+Res+Perspect
2017 ; 5
(2
): e00297
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Adverse reactions to fluoroquinolones in the Nigerian population: an audit of
reports submitted to the National Pharmacovigilance Centre from 2004 to 2016
#MMPMID28357123
Oreagba IA
; Oshikoya KA
; Ogar C
; Adefurin AO
; Ibrahim A
; Awodele O
; Oni Y
Pharmacol Res Perspect
2017[Apr]; 5
(2
): e00297
PMID28357123
show ga
Adverse drug reactions (ADRs) recorded in national pharmacovigilance databases in
developed countries have been analyzed. However, adverse reactions to
fluoroquinolones were observed globally despite their wide use and safety
concerns. We provided information on the pattern of adverse reactions to
fluoroquinolones reported spontaneously to the National Pharmacovigilance Centre
(NPC), Nigeria. ADRs to fluoroquinolones reported to the NPC, over a period of
12 years, were analyzed. Evaluation was done for annual reports, age and gender
of patients, type of reporter, suspected fluoroquinolones and adverse reactions,
onset and outcome of ADRs, and causality. A total of 18527 ADR reports were
received by the NPC. Antibiotics accounted for 1371(7.4%) of the total reports
and fluoroquinolones accounted for 256 (18.7%) cases. A total of 540 ADRs due to
fluoroquinolones was experienced by the patients. Multiple ADRs were experienced
by 165 (65%) patients. Norfloxacin (2; 0.8%), moxifloxacin (3; 1.2%), ofloxacin
(10; 3.9%), ciprofloxacin (112; 43.8%), and levofloxacin (129; 50.4%) were
responsible for the ADRs. Neurological disorders (121; 22.4%), gastrointestinal
disorders (118; 21.9%), and skin-appendage disorders (116; 21.5%) were the most
reported ADRs, while pruritus (41; 7.6%), abdominal pain (34; 6.3%), vomiting
(34; 6.3%), and skin rash (27; 5.0%) were the most frequently reported specific
ADRs. Thirty-four (6.4%) patients experienced serious ADRs. Fluoroquinolones
accounted for a small but significant proportion of ADRs spontaneously reported
to the NPC in Nigeria. Ciprofloxacin and levofloxacin were the two most culpable
fluoroquinolones due to their inappropriate use or increased use in multi-drug
resistant tuberculosis (MDR-TB) treatment.