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10.1038/srep45293 http://scihub22266oqcxt.onion/10.1038/srep45293 C5368596!5368596!28350011     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28350011|t=2017. Characterisation of male breast cancer: a descriptive biomarker study from a large patient series |pdf=|usr=}}{{28350011}} gab.com Text Characterisation of male breast cancer: a descriptive biomarker study from a large patient series JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28350011 #FOAvip Male breast cancer (MBC) is rare. We assembled 446 MBCs on tissue microarrays and assessed clinicopathological information, together with data from 15 published studies, totalling 1984 cases. By immunohistochemistry we investigated 14 biomarkers (ER?, ER?1, ER?2, ER?5, PR, AR, Bcl-2, HER2, p53, E-cadherin, Ki67, survivin, prolactin, FOXA1) for survival impact. The main histological subtype in our cohort and combined analyses was ductal (81%, 83%), grade 2; (40%, 44%), respectively. Cases were predominantly ER? (84%, 82%) and PR positive (74%, 71%), respectively, with HER2 expression being infrequent (2%, 10%), respectively. In our cohort, advanced age (>67) was the strongest predictor of overall (OS) and disease free survival (DFS) (p?=?0.00001; p?=?0.01, respectively). Node positivity negatively impacted DFS (p?=?0.04). FOXA1 p?=?0.005) and AR p?=?0.009) were both positively prognostic for DFS, remaining upon multivariate analysis. Network analysis showed ER?, AR and FOXA1 significantly correlated. In summary, the principle phenotype of MBC was luminal A, ductal, grade 2. In ER?+ MBC, only AR had prognostic significance, suggesting AR blockade could be employed therapeutically. Twit Text FOAVip Characterisation of male breast cancer: a descriptive biomarker study from a large patient series ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28350011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28350011 #FOAvip English Wikipedia <ref>{{Cite pmid|28350011}}</ref> Characterisation of male breast cancer: a descriptive biomarker study from a large patient series #MMPMID28350011 Humphries MP; Sundara Rajan S; Honarpisheh H; Cserni G; Dent J; Fulford L; Jordan LB; Jones JL; Kanthan R; Litwiniuk M; Di Benedetto A; Mottolese M; Provenzano E; Shousha S; Stephens M; Kulka J; Ellis IO; Titloye AN; Hanby AM; Shaaban AM; Speirs V Sci Rep 2017[]; 7 (ä): ä PMID28350011show ga Male breast cancer (MBC) is rare. We assembled 446 MBCs on tissue microarrays and assessed clinicopathological information, together with data from 15 published studies, totalling 1984 cases. By immunohistochemistry we investigated 14 biomarkers (ER?, ER?1, ER?2, ER?5, PR, AR, Bcl-2, HER2, p53, E-cadherin, Ki67, survivin, prolactin, FOXA1) for survival impact. The main histological subtype in our cohort and combined analyses was ductal (81%, 83%), grade 2; (40%, 44%), respectively. Cases were predominantly ER? (84%, 82%) and PR positive (74%, 71%), respectively, with HER2 expression being infrequent (2%, 10%), respectively. In our cohort, advanced age (>67) was the strongest predictor of overall (OS) and disease free survival (DFS) (p?=?0.00001; p?=?0.01, respectively). Node positivity negatively impacted DFS (p?=?0.04). FOXA1 p?=?0.005) and AR p?=?0.009) were both positively prognostic for DFS, remaining upon multivariate analysis. Network analysis showed ER?, AR and FOXA1 significantly correlated. In summary, the principle phenotype of MBC was luminal A, ductal, grade 2. In ER?+ MBC, only AR had prognostic significance, suggesting AR blockade could be employed therapeutically. äCharacterisation of male breast cancer: a descriptive biomarker study (epmc).pdf DeepDyve Pubget Overpricing