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10.1016/j.celrep.2017.02.046 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.02.046 C5368414!5368414!28297668     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 18 (11): 2635-50 Nephropedia Template TP {{tp|p=28297668|t=2017. Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate |pdf=|usr=}}{{28297668}} gab.com Text Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28297668 #FOAvip The nuclear cap-binding complex (CBC) stimulates processing reactions of capped RNAs, including their splicing, 3?-end formation, degradation, and transport. CBC effects are particular for individual RNA families, but how such selectivity is achieved remains elusive. Here, we analyze three main CBC partners known to impact different RNA species. ARS2 stimulates 3?-end formation/transcription termination of several transcript types, ZC3H18 stimulates degradation of a diverse set of RNAs, and PHAX functions in pre-small nuclear RNA/small nucleolar RNA (pre-snRNA/snoRNA) transport. Surprisingly, these proteins all bind capped RNAs without strong preferences for given transcripts, and their steady-state binding correlates poorly with their function. Despite this, PHAX and ZC3H18 compete for CBC binding and we demonstrate that this competitive binding is functionally relevant. We further show that CBC-containing complexes are short lived in vivo, and we therefore suggest that RNA fate involves the transient formation of mutually exclusive CBC complexes, which may only be consequential at particular checkpoints during RNA biogenesis. Twit Text FOAVip Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28297668 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28297668 #FOAvip English Wikipedia <ref>{{Cite pmid|28297668}}</ref> Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate #MMPMID28297668 Giacometti S; Benbahouche NEH; Domanski M; Robert MC; Meola N; Lubas M; Bukenborg J; Andersen JS; Schulze WM; Verheggen C; Kudla G; Jensen TH; Bertrand E Cell Rep 2017[Mar]; 18 (11): 2635-50 PMID28297668show ga The nuclear cap-binding complex (CBC) stimulates processing reactions of capped RNAs, including their splicing, 3?-end formation, degradation, and transport. CBC effects are particular for individual RNA families, but how such selectivity is achieved remains elusive. Here, we analyze three main CBC partners known to impact different RNA species. ARS2 stimulates 3?-end formation/transcription termination of several transcript types, ZC3H18 stimulates degradation of a diverse set of RNAs, and PHAX functions in pre-small nuclear RNA/small nucleolar RNA (pre-snRNA/snoRNA) transport. Surprisingly, these proteins all bind capped RNAs without strong preferences for given transcripts, and their steady-state binding correlates poorly with their function. Despite this, PHAX and ZC3H18 compete for CBC binding and we demonstrate that this competitive binding is functionally relevant. We further show that CBC-containing complexes are short lived in vivo, and we therefore suggest that RNA fate involves the transient formation of mutually exclusive CBC complexes, which may only be consequential at particular checkpoints during RNA biogenesis. äMutually Exclusive CBC-Containing Complexes Contribute to RNA Fate (epmc).pdf DeepDyve Pubget Overpricing