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10.3389/fphar.2017.00164

http://scihub22266oqcxt.onion/10.3389/fphar.2017.00164
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C5368178!5368178!28400732
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suck abstract from ncbi


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pmid28400732      Front+Pharmacol 2017 ; 8 (ä): ä
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  • How Factors Involved in the Resolution of Crystal-Induced Inflammation Target IL-1? #MMPMID28400732
  • Oliviero F; Scanu A
  • Front Pharmacol 2017[]; 8 (ä): ä PMID28400732show ga
  • One of the main clinical features characterizing crystal-induced inflammation is its spontaneous resolution. The aim of this review is to outline the various factors involved in the self-limiting course of crystal-induced inflammation focusing on their effect on IL-1? production. Endogenous molecules that are induced or locally recruited by the process itself, inhibitory proteins naturally present in the joint and exogenous dietary factors are discussed. Aside from the classical well-known molecules involved in the resolution of crystal-induced acute attack such as TGF?, IL-10, IL-1Ra, and lipoproteins, particular attention is paid to recently uncovered mechanisms such as the aggregation of neutrophil extracellular traps, the release of ectosomes from neutrophil surface, and alpha-1-anti-trypsin-mediated IL-1 inhibition.
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