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10.7554/eLife.22206 http://scihub22266oqcxt.onion/10.7554/eLife.22206 C5367895!5367895 !28186488     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28186488 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28186488 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28186488 |t=2017. Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation |pdf=|usr=}}{{28186488 }} gab.com Text Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28186488 #FOAvip The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation. Twit Text FOAVip Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28186488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28186488 #FOAvip English Wikipedia <ref>{{Cite pmid|28186488 }}</ref> Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation #MMPMID28186488 Fielding CA ; Weekes MP ; Nobre LV ; Ruckova E ; Wilkie GS ; Paulo JA ; Chang C ; Suárez NM ; Davies JA ; Antrobus R ; Stanton RJ ; Aicheler RJ ; Nichols H ; Vojtesek B ; Trowsdale J ; Davison AJ ; Gygi SP ; Tomasec P ; Lehner PJ ; Wilkinson GW Elife 2017[Feb]; 6 (ä): ä PMID28186488 show ga The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation. |*Host-Pathogen Interactions [MESH] |Cytomegalovirus/*immunology/*pathogenicity [MESH] |Humans [MESH] |Immune Evasion [MESH] |Immunologic Factors/*antagonists & inhibitors [MESH] |Killer Cells, Natural/*immunology [MESH] |Membrane Proteins/*antagonists & inhibitors [MESH] |Proteomics [MESH]Control of immune ligands by members of a cytomegalovirus gene expansi(epmc).pdf DeepDyve Pubget Overpricing